TJU HEALTH SCIENCES PLATFORM

Introduction

Donghua Wang ——Associate Professor
Nationality:	CHINA
Phone:	022-27409967
Email:	wdh022@tju.edu.cn
Office:	Room 446, Building 11, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	K-1098-2015
Group weblink

Education Experience

2006

Ph. D.

Tianjin University, CN

Professional Experience

1998-2004	lecturer	Tianjin University
1996-1998	assistant	Tianjin University
2004-2015	associate professor	Tianjin University

Research Area

The research in the group of Wang involves the design, synthesis, and biological activity evaluation of new compounds, with focus on industrialization of generic drugs, intermediates, and fine chemicals. Specific areas include 1) Design and synthesis of the Rho kinase inhibitor, 2) Design and synthesis of the PDE4 inhibitor, and 3) Design and synthesis of antihistamine drugs

Honors and Awards

Patents

Highlighted Publications

Lin,Y.; Wang, Y.; Sima, L-F.; Wang, D.-H.; Cao, X.-H.; Chen, L.-G.; Chen, B. Design, synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists. Bioorgan. Med. Chem. 2013, 21, 4178.

Lin,Y.; Huang, P.; Liu, S.; Sima, L.; Chen, L.; Wang, D.A convenient method for the synthesis of roflumilast. Res. Chem. Intermed. 2013, 39, 2107.

Chen, M.; Liu, S.; Wang, X.; Luo, H.; Chen, L.; Wang, D. Synthesis of 1-Isoquinolinol and Hydroxyfasudil. Chin. J. Org. Chem. 2012, 32, 404.

Wang, Y.; Wang, J.; Lin, Y.; Si-Ma, L.-F.; Wang, D.-H. Chen, L.-G.; Deng-Ke, L. Synthesis and Antihistamine Evaluations of Novel Loratadine Analogues. Bioorgan. Med. Chem. 2011, 21, 4454.

Wang, D.; Qu, W.; Shi, L.; Wei, J. Molecular Docking and Pharmacophore Model Studies of Rho Kinase Inhibitors. Mol. Simulat. 2011, 37, 488.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2015	Design, Synthesis, and Biological Evaluations of Several Y-26732 Analogues	Wang, Xinran; Chen, Ligong; Li, Hang; et al.	Journal of Heterocyclic Chemistry	52
2015	Synthesis and structure confirmation of the impurity in crude roflumilast product	Sun, Chang-hai; Lin, Yan; Sun, Meng; et al.	Research on Chemical Intermediates	41
2014	Design, synthesis and evaluation of biological activity of novel fasudil analogues	Li, Hang; Wang, Donghua; Liu, Shuai; et al.	Pharmazie	69
2014	Synthesis of an impurity in crude roflumilast	Zhang, Hankang; Lin, Yan; Li, Yan; et al.	Journal of Chemical Research
2013	A convenient method for the synthesis of roflumilast	Lin, Yan; Huang, Peijun; Liu, Shuai; et al.	Research on Chemical Intermediates	39
2013	Design, synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists	Lin, Yan; Wang, Yue; Sima, Li-Feng; et al.	Bioorganic & Medicinal Chemistry	21
2013	Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product	Lin, Yan; Huang, Peijun; Qi, Haofei; et al.	Research on Chemical Intermediates	39
2012	Design, Synthesis and Antihistamine Evaluations of Several N-hydroxyalkyl Desloratadine Analogues	Lin, Yan; Wang, Yue; Sima, Li-feng; et al.	Medicinal Chemistry	8
2012	Highly Selective Amination of o- and p-Alkyl Phenols over Pd/Al2O3-BaO	Ma, Jianchao; Wang, Huabang; Sun, Meng; et al.	Bulletin of the Korean Chemical Society	33
2012	Synthesis of 1-Isoquinolinol and Hydroxyfasudil	Chen Meizhu; Liu Shuai; Wang Xinran; et al.	Chinese Journal of Organic Chemistry	32
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Donghua Wang ——Associate Professor

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