TJU HEALTH SCIENCES PLATFORM

Introduction

Donghua Wang ——Associate Professor
Nationality:	CHINA
Phone:	022-27409967
Email:	wdh022@tju.edu.cn
Office:	Room 446, Building 11, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	K-1098-2015
Group weblink

Education Experience

2006

Ph. D.

Tianjin University, CN

Professional Experience

1998-2004	lecturer	Tianjin University
1996-1998	assistant	Tianjin University
2004-2015	associate professor	Tianjin University

Research Area

The research in the group of Wang involves the design, synthesis, and biological activity evaluation of new compounds, with focus on industrialization of generic drugs, intermediates, and fine chemicals. Specific areas include 1) Design and synthesis of the Rho kinase inhibitor, 2) Design and synthesis of the PDE4 inhibitor, and 3) Design and synthesis of antihistamine drugs

Honors and Awards

Patents

Highlighted Publications

Lin,Y.; Wang, Y.; Sima, L-F.; Wang, D.-H.; Cao, X.-H.; Chen, L.-G.; Chen, B. Design, synthesis and biological activity evaluation of desloratadine analogues as H-1 receptor antagonists. Bioorgan. Med. Chem. 2013, 21, 4178.

Lin,Y.; Huang, P.; Liu, S.; Sima, L.; Chen, L.; Wang, D.A convenient method for the synthesis of roflumilast. Res. Chem. Intermed. 2013, 39, 2107.

Chen, M.; Liu, S.; Wang, X.; Luo, H.; Chen, L.; Wang, D. Synthesis of 1-Isoquinolinol and Hydroxyfasudil. Chin. J. Org. Chem. 2012, 32, 404.

Wang, Y.; Wang, J.; Lin, Y.; Si-Ma, L.-F.; Wang, D.-H. Chen, L.-G.; Deng-Ke, L. Synthesis and Antihistamine Evaluations of Novel Loratadine Analogues. Bioorgan. Med. Chem. 2011, 21, 4454.

Wang, D.; Qu, W.; Shi, L.; Wei, J. Molecular Docking and Pharmacophore Model Studies of Rho Kinase Inhibitors. Mol. Simulat. 2011, 37, 488.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2011	Molecular docking and pharmacophore model studies of Rho kinase inhibitors	Wang, Dong-Hua; Qu, Wan-Lu; Shi, Liu-Qing; et al.	Molecular Simulation	37
2011	Synthesis and antihistamine evaluations of novel loratadine analogues	Wang, Yue; Wang, Juan; Lin, Yan; et al.	Bioorganic & Medicinal Chemistry Letters	21
2011	Synthesis and antihistamine evaluations of novel loratadine analogues (vol 21, pg 4454, 2011)	Wang, Yue; Wang, Juan; Lin, Yan; et al.	Bioorganic & Medicinal Chemistry Letters	21
2010	The role of iron in the selective amination of 1,2-butanediol to 2-amino-1-butanol over Co-Ba-Fe/gamma-Al2O3	Zhao, Guangle; Yu, Liang; Yan, Xilong; et al.	Reaction Kinetics Mechanisms and Catalysis	100
2009	Preparation of polystyrene fluorescent microspheres based on some fluorescent labels	Liu, Qing-Hao; Liu, Jia; Guo, Jin-Chun; et al.	Journal of Materials Chemistry	19
2009	Selective Hydrolysis and Decarboxylation of Methyl [1-(2-Cyanoethyl)-2-oxocyclopentyl]carboxylate	Zhao Guangle; Yu Liang; Yan Xilong; et al.	Chinese Journal of Organic Chemistry	29
2009	Spectrofluorimetric determination of trace nitrite with a novel fluorescent probe	Liu, Qing-Hao; Yan, Xi-Long; Guo, Jin-Chun; et al.	Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy	73
2009	Synthesis of 6,7-Dihydro-5H-1-pyrindine	Chen Yanxue; Zhao Guangle; Li Yang; et al.	Chinese Journal of Organic Chemistry	29
2005	Novel approach to 3-methyl-1H-quinoxalin-2-ones	Li, X; Wang, DH; Wu, JF; et al.	Synthetic Communications	35
2005	Synthesis of substituted 1,3-dimethyl-1H-quinoxalin-2-ones from aniline derivatives	Li, X; Wang, DH; Wu, JF; et al.	Heterocycles	65
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Donghua Wang ——Associate Professor

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