TJU HEALTH SCIENCES PLATFORM

Introduction

Haitao Yang——Professor
Nationality:	China
Phone:	022-27403959
Email:	yanght@tju.edu.cn
Office:	School of Life Sciences Tianjin University 92 Weijin Road, Nankai District, Tianjin 300072, P.R.China
School:	School of Life Sciences
ResearcherID:	G-9116-2012
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Education Experience

2001-2006

Ph. D.

Tsinghua University

Professional Experience

2006-2011	Postdoc	Yale University
2011-2013	Associate Research Scientist	Yale University
2013-	Professor	Tianjin University

Research Area

Viruses are significant pathogens involved in human diseases throughout human history. Many of these virus-related human diseases have zoonotic origins, such as AIDS, bird flu, and severe acute respiratory syndrome (SARS). We focus on the essential stages of the viral life cycle: cellular entry, replication and transcription of the viral genome, and virion assembly and release to identify the pivotal targets for drug development.

To study the underlying mechanisms of interplay between viruses and their hosts will also help reveal new drug targets. Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Interestingly, the viruses have evolved a variety of strategies to antagonize host restriction and escape the innate immune response. The interaction between host antiviral proteins and viral antagonizing proteins constitutes a dynamic and sophisticated network. Thus, strategies that boost the roles of host restriction while diminishing viral antagonism may lead to new therapies against viral infection.

Honors and Awards

1000 Talent Awardee (Young Scientist)

Patents

2. Zihe Rao, Haitao Yang, Yinghua Jin, Xiaoyu Xue, Kailin Yang. EXPRESSION VECTOR BASED ON CORONAVIRUS PROTEOLYTIC CLEAVAGE AND ITS APPLICATION. Chinese patent, application number CN200510063088.2.

1. Zihe Rao, Haitao Yang, Xiaoyu Xue, Kailin Yang, Mark Bartlam, Dawei Ma, Weiqing Xie. SMALL-MOLECULE INHIBITORS OF CORONAVIRAL MAIN PROTEASE, THEIR PREPARATION AND USE. Chinese application number: 200410087721.7; Chinese granted number: CN 100363346C; international application number: PCT/CN2005/001748.

Highlighted Publications

5. Yang H#, Yang M#, Ding Y#, Liu Y, Lou Z, Zhou Z, Sun L, Mo L, Ye S, Pang H, et al.: The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A 2003, 100:13190-13195.(#These authors contributed equally to this work)

4. Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, et al.: Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases. PLoS Biol 2005, 3:e324.

3. Yang H#, Wang J#, Jia X, McNatt M., Zang T, Pan B, Meng W, Wang W, Bieniasz P and Xiong Y: Structural Insight into the Mechanisms of Enveloped Virus Tethering by Tetherin. Proc Natl Acad Sci U S A 2010, 107: 18428–18432. (#These authors contributed equally to this work)

2. Yang H#, Ji X#, Zhao G, Ning J, Zhao Q, Aiken C,. Gronenborn AM, Zhang P, Xiong Y: Structural Insight into HIV-1 Capsid Recognition by Rhesus TRIM5α. Proc Natl Acad Sci U S A2012, 109:18372-18377. (#These authors contributed equally to this work)

1. Ji X, Wu Y, Yan J, Mehrens J, Yang H, Delucia M, Hao C, Gronenborn AM, Skowronski J, Ahn J, Xiong Y:Mechanism of allosteric activation of SAMHD1 by dGTP. Nature Struct. Mol. Biol. 2013,20:1304-1309.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2004	Cloning, expression, purification and crystallization of NHR3 domain from acute myelogenous leukemia-related protein AML1-ETO	Yang, H. T.; Wu, D. H.; Xue, X. Y.; et al.	Acta Biochimica Et Biophysica Sinica	36
2004	Crystal structure of an acylpeptide hydrolase/esterase from Aeropyrum pernix K1	Bartlam, M.; Wang, G. G.; Yang, H. T.; et al.	Structure	12
2004	Crystallization and preliminary crystallographic analysis of a native chitinase from the fungal pathogen Aspergillus fumigatus YJ-407	Hu, H. Y.; Wang, G. G.; Yang, H. T.; et al.	Acta Crystallographica Section D-Biological Crystallography	60
2003	Archaeal acylamino acid releasing enzyme/lipase: Crystallization and preliminary crystallographic analysis in a new crystal form	Wang, G. G.; Gao, R. J.; Yang, H. T.; et al.	Chinese Science Bulletin	48
2003	Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschiii	Wang, G. G.; Guo, R.; Bartlam, M.; et al.	Protein Science	12
2003	Improvement on diffraction resolution of an archaeon DNA binding protein by gel medium	Wang, G. G.; Yang, H. T.; Rao, Z. H.	Progress in Biochemistry and Biophysics	30
2003	The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor	Yang, H. T.; Yang, M. J.; Ding, Y.; et al.	Proceedings of the National Academy of Sciences of the United States of America	100
2002	Crystallization and preliminary crystallographic analysis of acylamino-acid releasing enzyme from the hyperthermophilic archaeon Aeropyrum pernix	Wang, G. G.; Gao, R. J.; Ding, Y.; et al.	Acta Crystallographica Section D-Biological Crystallography	58
2002	Expression, purification, crystallization and preliminary X-ray analysis of a DNA-binding protein from Methanococcus jannaschii	Wang, G. G.; Guo, R.; Bartlam, M.; et al.	Acta Crystallographica Section D-Biological Crystallography	58
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Haitao Yang——Professor

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