TJU HEALTH SCIENCES PLATFORM

Introduction

Jun Dai ——Associate Professor
Nationality:	CHINA
Phone:	022-87401830
Email:	jun.dai@tju.edu.cn
Office:	Room A303, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	J-9718-2015
Group weblink

Education Experience

2000	Ph. D.	Tulane University, LA
2000	Postdoctoral	Brigham and Womens Hospital, Boston, MA

Professional Experience

2008-2014	Instructor in Dermatology	Massachusetts General Hospital/Harvard Medical School
2005-2008	Instructor in Medicine	Brigham and Women’s Hospital/Harvard Medical School
2000-2005	Postdoctoral Fellow	Brigham and Women’s Hospital, Boston, MA

Research Area

The research efforts of the Dai group encompass two areas: 1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin. In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases. In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

Honors and Awards

Patents

Highlighted Publications

Dai, J.; Brooks, Y.; Lefort, K.; Getsios, S.; Dotto, G. P. The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS ONE 2013, 8, e70392.

Wang, F.; Dai, J.; Daum, J. R.; Niedzialkowska E.; Banerjee B.; Stukenberg T.; Gorbsky G. J.; Higgins, J. M. Histone H3 Thr-3 phosphorylation by haspin positions Aurora B at centromeres in mitosis. Science 2010, 330, 231.

Dai, J.; Kateneva, A. V.; Higgins, J. M. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J. Cell Sci. 2009, 122, 4148.

Dai, J.; Sullivan, B. A.; Higgins, J. M. Regulation of mitotic chromosome cohesion by haspin and aurora B. Dev. Cell 2006; 11, 741. (Featured cover illustration)

Dai, J.; Sultan, S.; Taylor, S. S.; Higgins, J. M. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes & Dev. 2005, 19, 472. (Featured cover illustration)

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2004	ACAP1 promotes endocytic recycling - Short article by recognizing recycling sorting signals	Dai, J; Li, J; Bos, E; et al.	Developmental Cell	7
2002	Involvement of the mt1 melatonin receptor in human breast cancer	Ram, PT; Dai, J; Yuan, L; et al.	Cancer Letters	179
2002	Modulation of intracellular calcium and calmodulin by melatonin in MCF-7 human breast cancer cells	Dai, J; Inscho, EW; Yuan, L; et al.	Journal of Pineal Research	32
2002	MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells	Yuan, L; Collins, AR; Dai, J; et al.	Molecular and Cellular Endocrinology	192
2002	Tumor prevention by 9-cis-retinoic acid in the N-nitroso-N-methylurea model of mammary carcinogenesis is potentiated by the pineal hormone melatonin	Nowfar, S; Teplitzky, SR; Melancon, K; et al.	Breast Cancer Research and Treatment	72
2001	Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid	Teplitzky, SR; Kiefer, TL; Cheng, Q; et al.	Cancer Letters	168
2001	Transcriptional repression of RORalpha activity in human breast cancer cells by melatonin.	Dai, J; Ram, P T; Yuan, L; et al.	Molecular and cellular endocrinology	176
2000	Differential responsiveness of MCF-7 human breast cancer cell line stocks to the pineal hormone, melatonin	Ram, PT; Yuan, L; Dai, J; et al.	Journal of Pineal Research	28
	Determining if a test compound inhibits haspin kinase activity, comprises incubating a solution comprising haspin and a polypeptide, for phosphorylation; and determining test compound the inhibits phosphorylation of the polypeptide	HIGGINS J M G; DAI J
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Jun Dai ——Associate Professor

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