TJU HEALTH SCIENCES PLATFORM

Introduction

Jun Dai ——Associate Professor
Nationality:	CHINA
Phone:	022-87401830
Email:	jun.dai@tju.edu.cn
Office:	Room A303, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	J-9718-2015
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Education Experience

2000	Ph. D.	Tulane University, LA
2000	Postdoctoral	Brigham and Womens Hospital, Boston, MA

Professional Experience

2008-2014	Instructor in Dermatology	Massachusetts General Hospital/Harvard Medical School
2005-2008	Instructor in Medicine	Brigham and Women’s Hospital/Harvard Medical School
2000-2005	Postdoctoral Fellow	Brigham and Women’s Hospital, Boston, MA

Research Area

The research efforts of the Dai group encompass two areas: 1) The role of retinoid-related orphan receptor RORα in controlling skin homeostatis, and 2) Control of normal mitosis by protein kinase haspin. In the first area, the main interest is on the interplay between intra- and inter-cellular signaling pathways involved in control of skin tissue homeostasis and tumor development. Focuses on the role of the nuclear orphan receptor RORα in controlling keratinocyte differentiation and skin tumor formation, as well as the therapeutic potential of RORα agonists/antagonists in treatment of skin diseases. In the second area, the group is interested in exploring the role of haspin in cancer development and the potential of haspin inhibitors as anti-tumor drugs.

Honors and Awards

Patents

Highlighted Publications

Dai, J.; Brooks, Y.; Lefort, K.; Getsios, S.; Dotto, G. P. The retinoid-related orphan receptor RORα promotes keratinocyte differentiation via FOXN1. PLoS ONE 2013, 8, e70392.

Wang, F.; Dai, J.; Daum, J. R.; Niedzialkowska E.; Banerjee B.; Stukenberg T.; Gorbsky G. J.; Higgins, J. M. Histone H3 Thr-3 phosphorylation by haspin positions Aurora B at centromeres in mitosis. Science 2010, 330, 231.

Dai, J.; Kateneva, A. V.; Higgins, J. M. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J. Cell Sci. 2009, 122, 4148.

Dai, J.; Sullivan, B. A.; Higgins, J. M. Regulation of mitotic chromosome cohesion by haspin and aurora B. Dev. Cell 2006; 11, 741. (Featured cover illustration)

Dai, J.; Sultan, S.; Taylor, S. S.; Higgins, J. M. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes & Dev. 2005, 19, 472. (Featured cover illustration)

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2014	Multifactorial ER beta and NOTCH1 control of squamous differentiation and cancer	Brooks, Yang Sui; Ostano, Paola; Jo, Seung-Hee; et al.	Journal of Clinical Investigation	124
2013	The Retinoid-Related Orphan Receptor ROR alpha Promotes Keratinocyte Differentiation via FOXN1	Dai, Jun; Brooks, Yang; Lefort, Karine; et al.	Plos One	8
2010	Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis	Wang, Fangwei; Dai, Jun; Daum, John R.; et al.	Science	330
2010	Melatonin inhibits mitogenic cross-talk between retinoic acid-related orphan receptor alpha (ROR alpha) and ER alpha in MCF-7 human breast cancer cells	Dong, Chunmin; Yuan, Lin; Dai, Jun; et al.	Steroids	75
2009	Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion	Dai, Jun; Kateneva, Anna V.; Higgins, Jonathan M. G.	Journal of Cell Science	122
2007	An ACAP1-containing clathrin coat complex for endocytic recycling	Li, Jian; Peters, Peter J.; Bai, Ming; et al.	Journal of Cell Biology	178
2006	Regulation of mitotic chromosome cohesion by Haspin and Aurora B	Dai, Jun; Sullivan, Beth A.; Higgins, Jonathan M. G.	Developmental Cell	11
2005	Haspin - A mitotic histone kinase required for metaphase chromosome alignment	Dai, J; Higgins, JMG	Cell Cycle	4
2005	Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta 1 to control cell migration	Li, J; Ballif, BA; Powelka, AM; et al.	Developmental Cell	9
2005	The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment	Dai, J; Sultan, S; Taylor, SS; et al.	Genes & Development	19
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Jun Dai ——Associate Professor

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