Home / People / / Youcai Zhang

Youcai Zhang——Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
youcai.zhang@tju.edu.cn
Office:
Room 3107, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2011 Ph. D. Pharmacology and Toxicology University of Kansas Medical Center
2013-2014 Postdoctoral Bioengineering University of California San Francisco
Professional Experience
2011-2013 Associate Scientist Elan Pharmaceutics Inc
2013-2014 Principle Scientist Apricity Therapeutics
Research Area

研究方向为药理毒理学,主持国自然面上项目、973计划子课题、天津市科委项目等,近5年作为唯一通讯或最后主通讯以天津大学为第一单位在《Pharmacological Reviews》杂志(IF:18,年均发文量28)、《Hepatology》(IF:15, 2篇)、《Nature Communications(IF:14)、《Journal of Experimental and Clinical Cancer Research(IF:12)等领域内顶刊发表多篇SCI论文。担任美国毒理学会官方杂志《Toxicological Sciences》副主编、美国生物化学和分子生物学会杂志《Journal of Lipid Research》编委、国内杂志《Medicine Advances》编委等。

Honors and Awards
Associate Editor, Toxicological Sciences
Editor board member, Journal of Lipid Research
Patents
Highlighted Publications
1. Wang X, Luo J, Han L, Xu T, Wang H, Zhang M, Li G, Li X, Zhang W, Zhang Y (2025). FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis. Hepatology (in press) (唯一通讯)
1. Wang X, Klaassen CD, Chen X, Zhang Y* (2025). Pathological and therapeutic roles of bile acid metabolism and signaling in hepatocellular carcinoma: insights from human and mouse studies. Pharmacological Reviews, 77(5): 100073.(唯一通讯)
Xu T, Li X, Zhao W, Wang X, Jin L, Feng Z, Li H, Zhang M, Tian Y, Hu G, Yue Y, Dai X, Shan C, Zhang W, Zhang C, Zhang Y. SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis, Journal of Experimental&Clinical Cancer Research, 2024 (主通讯)
Zhao W, Wang X, Han L, Zhang C, Wang C, Kong D, Zhang M, Xu T, Li G, Hu G, Luo J, Yee SW, Yang J, Stahl A, Chen X, Zhang Y. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis, Nature Communications, 2024 (主通讯)
Hui Xiong, Chunze Zhang, Lifeng Han, Tong Xu, Khawar Saeed, Jing Han, Jing Liu, Curtis D. Klaassen, Frank J Gonzalez, Yuanfu Lu, Youcai Zhang, Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity, Hepatology, 2022 (主通讯)
ResearcherID Publications
Year Title Author(s) Source Volume
2011 MOUSE STRAIN DIFFERENCES IN BILE ACID HOMEOSTASIS Csanaky, Ivan L.; Zhang, Youcai; Klaassen, Curtis D. Hepatology 54
2011 NUTRIENT REGULATION OF CYP7A1 EXPRESSION LINKS BILE ACID SYNTHESIS TO MAINTAIN METABOLIC HOMEOSTASIS AND PREVENT DIABETES AND OBESITY Li, Tiangang; Boehme, Shannon M.; Ochoa, Adrian; et al. Hepatology 54
2011 Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) Is Important for the Hepatic Uptake of Unconjugated Bile Acids: Studies in Oatp1b2-Null Mice Csanaky, Ivan L.; Lu, Hong; Zhang, Youcai; et al. Hepatology 53
2010 Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice Zhang, Youcai; Klaassen, Curtis D. Journal of Lipid Research 51
2008 Synthesis, structure and nonlinear optical properties of three dimensional compounds Pan, Zhao Rui; Zhang, You Cai; Song, Ying Lin; et al. Journal of Coordination Chemistry 61
2008 The Nrf2 activator oltipraz also activates the constitutive androstane receptor Merrell, Matthew D.; Jackson, Jonathan P.; Augustine, Lisa M.; et al. Drug Metabolism and Disposition 36
2006 Bis(2,2 ’-bipyridine)iodo(oxo)tri-mu(3)-sulfido-tricopper(I)tungsten(VI) Li, WG; Zhang, YC; Wang, ZW; et al. Acta Crystallographica Section C-Crystal Structure Communications 62
2005 Recent progress on Mo(W)/Cu(Ag,Au)/S heterothiometallic polymeric clusters Zhang, YC; Liang, K; Chen, QY; et al. Chinese Journal of Inorganic Chemistry 21
2004 A new type of [2] and [3]pseudorotaxane composed of beta-cyclodextrin and bisimidazolyl compounds Shen, XJ; Chen, HL; Yu, F; et al. Tetrahedron Letters 45
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