Home / People / / Youcai Zhang

Youcai Zhang——Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
youcai.zhang@tju.edu.cn
Office:
Room 3107, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2011 Ph. D. Pharmacology and Toxicology University of Kansas Medical Center
2013-2014 Postdoctoral Bioengineering University of California San Francisco
Professional Experience
2011-2013 Associate Scientist Elan Pharmaceutics Inc
2013-2014 Principle Scientist Apricity Therapeutics
Research Area

研究方向为疾病药物靶点发现、疾病诊断、安全评价等,承担和参与国家自然科学基金面上项目以及科技部、中医药管理局等重大研发计划,近5年作为主通讯作者在Hepatology、Nature Communications、JECCR等杂志上发表多篇SCI论文。担任美国毒理学会官方杂志《Toxicological Sciences》副主编、美国生物化学和分子生物学会杂志《Journal of Lipid Research》编委、国内杂志《Medicine Advances》编委。

Honors and Awards
Associate Editor, Toxicological Sciences
Editor board member, Journal of Lipid Research
Patents
Highlighted Publications
Xu T, Li X, Zhao W, Wang X, Jin L, Feng Z, Li H, Zhang M, Tian Y, Hu G, Yue Y, Dai X, Shan C, Zhang W, Zhang C, Zhang Y. SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis, Journal of Experimental&Clinical Cancer Research, 2024
Zhao W, Wang X, Han L, Zhang C, Wang C, Kong D, Zhang M, Xu T, Li G, Hu G, Luo J, Yee SW, Yang J, Stahl A, Chen X, Zhang Y. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis, Nature Communications, 2024
Hui Xiong, Chunze Zhang, Lifeng Han, Tong Xu, Khawar Saeed, Jing Han, Jing Liu, Curtis D. Klaassen, Frank J Gonzalez, Yuanfu Lu, Youcai Zhang, Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity, Hepatology, 2022
ResearcherID Publications
Year Title Author(s) Source Volume
2012 Effect of bile duct ligation on bile acid composition in mouse serum and liver Zhang, Youcai; Hong, Ji-Young; Rockwell, Cheryl E.; et al. Liver International 32
2012 Glucose and Insulin Induction of Bile Acid Synthesis MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY Li, Tiangang; Francl, Jessica M.; Boehme, Shannon; et al. Journal of Biological Chemistry 287
2012 Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice Kong, Bo; Wang, Li; Chiang, John Y. L.; et al. Hepatology 56
2012 Nrf2 protects against diquat-induced liver and lung injury Wu, Kai Connie; Zhang, Youcai; Klaassen, Curtis D. Free Radical Research 46
2012 Organic Anion Transporting Polypeptide 1a1 Null Mice Are Sensitive to Cholestatic Liver Injury Zhang, Youcai; Csanaky, Ivan L.; Cheng, Xingguo; et al. Toxicological Sciences 127
2012 Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice Zhang, Youcai; Cheng, Xingguo; Aleksunes, Lauren; et al. Drug Metabolism and Disposition 40
2011 Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles Gong, Lei; Aranibar, Nelly; Han, Yong-Hae; et al. Toxicological Sciences 122
2011 Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice Song, Peizhen; Zhang, Youcai; Klaassen, Curtis D. Toxicological Sciences 123
2011 LOSS OF OATP1A1 FUNCTION INCREASES DEOXYCHOLIC ACID HEPATOTOXICITY IN MICE BY INCREASING INTESTINAL PERMEABILITY Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Hepatology 54
2011 Loss of Organic Anion Transporting Polypeptide 1a1 Increases Deoxycholic Acid Absorption in Mice by Increasing Intestinal Permeability Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Toxicological Sciences 124
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