Home / People / / Youcai Zhang

Youcai Zhang——Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
youcai.zhang@tju.edu.cn
Office:
Room 3107, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2011 Ph. D. Pharmacology and Toxicology University of Kansas Medical Center
2013-2014 Postdoctoral Bioengineering University of California San Francisco
Professional Experience
2011-2013 Associate Scientist Elan Pharmaceutics Inc
2013-2014 Principle Scientist Apricity Therapeutics
Research Area

研究方向为药理毒理学,主持国自然面上项目、973计划子课题、天津市科委项目等,近5年作为唯一通讯或最后主通讯以天津大学为第一单位在《Pharmacological Reviews》杂志(IF:18,年均发文量28)、《Hepatology》(IF:15, 2篇)、《Nature Communications(IF:14)、《Journal of Experimental and Clinical Cancer Research(IF:12)等领域内顶刊发表多篇SCI论文。担任美国毒理学会官方杂志《Toxicological Sciences》副主编、美国生物化学和分子生物学会杂志《Journal of Lipid Research》编委、国内杂志《Medicine Advances》编委等。

Honors and Awards
Associate Editor, Toxicological Sciences
Editor board member, Journal of Lipid Research
Patents
Highlighted Publications
1. Wang X, Luo J, Han L, Xu T, Wang H, Zhang M, Li G, Li X, Zhang W, Zhang Y (2025). FXR splicing by SF3B3 promotes MYC-driven hepatocarcinogenesis. Hepatology (in press) (唯一通讯)
1. Wang X, Klaassen CD, Chen X, Zhang Y* (2025). Pathological and therapeutic roles of bile acid metabolism and signaling in hepatocellular carcinoma: insights from human and mouse studies. Pharmacological Reviews, 77(5): 100073.(唯一通讯)
Xu T, Li X, Zhao W, Wang X, Jin L, Feng Z, Li H, Zhang M, Tian Y, Hu G, Yue Y, Dai X, Shan C, Zhang W, Zhang C, Zhang Y. SF3B3-regulated mTOR alternative splicing promotes colorectal cancer progression and metastasis, Journal of Experimental&Clinical Cancer Research, 2024 (主通讯)
Zhao W, Wang X, Han L, Zhang C, Wang C, Kong D, Zhang M, Xu T, Li G, Hu G, Luo J, Yee SW, Yang J, Stahl A, Chen X, Zhang Y. SLC13A3 is a major effector downstream of activated β-catenin in liver cancer pathogenesis, Nature Communications, 2024 (主通讯)
Hui Xiong, Chunze Zhang, Lifeng Han, Tong Xu, Khawar Saeed, Jing Han, Jing Liu, Curtis D. Klaassen, Frank J Gonzalez, Yuanfu Lu, Youcai Zhang, Suppressed farnesoid X receptor by iron overload in mice and humans potentiates iron-induced hepatotoxicity, Hepatology, 2022 (主通讯)
ResearcherID Publications
Year Title Author(s) Source Volume
2012 Effect of bile duct ligation on bile acid composition in mouse serum and liver Zhang, Youcai; Hong, Ji-Young; Rockwell, Cheryl E.; et al. Liver International 32
2012 Glucose and Insulin Induction of Bile Acid Synthesis MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY Li, Tiangang; Francl, Jessica M.; Boehme, Shannon; et al. Journal of Biological Chemistry 287
2012 Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice Kong, Bo; Wang, Li; Chiang, John Y. L.; et al. Hepatology 56
2012 Nrf2 protects against diquat-induced liver and lung injury Wu, Kai Connie; Zhang, Youcai; Klaassen, Curtis D. Free Radical Research 46
2012 Organic Anion Transporting Polypeptide 1a1 Null Mice Are Sensitive to Cholestatic Liver Injury Zhang, Youcai; Csanaky, Ivan L.; Cheng, Xingguo; et al. Toxicological Sciences 127
2012 Transcription Factor-Mediated Regulation of Carboxylesterase Enzymes in Livers of Mice Zhang, Youcai; Cheng, Xingguo; Aleksunes, Lauren; et al. Drug Metabolism and Disposition 40
2011 Characterization of Organic Anion-Transporting Polypeptide (Oatp) 1a1 and 1a4 Null Mice Reveals Altered Transport Function and Urinary Metabolomic Profiles Gong, Lei; Aranibar, Nelly; Han, Yong-Hae; et al. Toxicological Sciences 122
2011 Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice Song, Peizhen; Zhang, Youcai; Klaassen, Curtis D. Toxicological Sciences 123
2011 LOSS OF OATP1A1 FUNCTION INCREASES DEOXYCHOLIC ACID HEPATOTOXICITY IN MICE BY INCREASING INTESTINAL PERMEABILITY Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Hepatology 54
2011 Loss of Organic Anion Transporting Polypeptide 1a1 Increases Deoxycholic Acid Absorption in Mice by Increasing Intestinal Permeability Zhang, Youcai; Csanaky, Ivan L.; Lehman-McKeeman, Lois D.; et al. Toxicological Sciences 124
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