TJU HEALTH SCIENCES PLATFORM

Introduction

Jianhui Huang——Professor
Nationality:	CHINA
Phone:	022-27409894
Email:	jhuang@tju.edu.cn
Office:	Office 514C, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	H-1552-2011
Group weblink
	http://huang.tju.edu.cn

Education Experience

2003-2006	Doctor of Philosophy Chemistry	University of York, UK
1996-2000	Bachelor of Science Chemistry	Hu'nan University

Professional Experience

2007-2010	Postdoctorial Research Associate	University of Sheffield and GlaxoSmithKlein
2010-2023	Associate Professor/Professor	Tianjin University, China

Research Area

The research of the Huang group encompasses the following main areas:

1) Molecular design (AIDD & Chiral Catalyst/ligand Design)

2) XDC Drug Development and Preparation (Protac/RDC...)

3) New Chemical Space Exploration

Honors and Awards

Teaching Award, HSP, Tianjin University, 2018

Thieme Chemistry Journal Award, 2017

Best Publication Award, HSP, Tianjin University, 2015

Patents

黄剑辉; 刘柳; 曾凡云; 陈晨; 李一凡 ; 手性二胺类化合物和应用以及亚胺的不对称加成方法, 2021-04-14, 中国, ZL202110401309.1 (专利)

钌催化下的2－（3－溴苯基）吡啶类衍生物的合成， 2015031900635430，黄剑辉、于庆贞、胡乐安、王悦、赵康， 2016.09

3-羟基-2-烷氧基-3-苯基异吲哚-1(2H)-酮类衍生物的制备方法， 2013102117068，黄剑辉、刘伟东、朱怡、于庆贞、张娜娜， 2015.07

Highlighted Publications

Qing Wang,† Fanhao Meng,† Yuting Xie, Wei Wang, Yumin Meng, Linjie Li, Tao Liu, Jianxun Qi, Xiaodan Ni, Sanduo Zheng, Jianhui Huang,* Niu Huang.* In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV- 2 Spike Protein. ACS Cent. Sci. 2023. 9, 252–265. doi: 10.1021/acscentsci.2c01190.

Xiaoli Qin, Lin Huang, Ziying Zhan, Peng Fu, Congyang Zhang, Jianhui Huang, Zhifeng Ding.“Enhancing corannulene electrochemiluminescence and chemiluminescence by means of an Azabora-helicene to slow down its bowl inversion.” Chem. Sci., 2024, accepted.

Lin Huang, Qing Wang, Peng Fu, Yuzhu Sun, Duncan Browne, Jianhui Huang. “Extended Quinolizinium-Fused Corannulene Derivatives: Synthesis and Properties.”JACS Au (An Open Access Journal of The American Chemical Society), 2024, 4, 1623-1631.

Lin Huang. Mengyu Qiu, Zhihao Chang, Duncan Browne, Jianhui Huang.“C–H Activation Enabled Piperazine-Embedded Azadibenzo[a,g]corannulene Synthesis.”Org. Chem. Front., 2024, 11, 2807-2814.

Q. Yu; L. Hu; Y. Wang; S. Zheng; J. Huang "Directed meta-selective bromination of arenes with ruthenium catalysts." Angew. Chem. Int. Ed., 2015, 54, 15284-15288.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2012	Synthesis of N-alkyl and N-aryl isoquinolones and derivatives via Pd-catalysed C-H activation and cyclization reactions	Zhang, Nana; Li, Binyao; Zhong, Hongban; et al.	Organic & Biomolecular Chemistry	10
2012	Synthesis of Functionalized Fluorescent Indenes from Electron-Rich alpha-Aryl Ketonitriles	Liu, Le; Fan, Yanfeng; He, Qiaoqiao; et al.	Journal of Organic Chemistry	77
2012	Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activation	Zhong, Hongban; Yang, Dan; Wang, Songqing; et al.	Chemical Communications	48
2012	Copper(II)-Mediated Cascade Oxidative C-C Coupling and Aromatization: Synthesis of 3-Hydroxyphenanthridinone Derivatives	Yu, Qingzhen; Zhang, Nan; Tang, Yang; et al.	Synthesis-Stuttgart	44
2013	Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction	Zhang, Nana; Yu, Qingzhen; Chen, Ruixue; et al.	Chemical Communications	49
2013	Pd-catalysed direct dehydrogenative carboxylation of alkenes: facile synthesis of vinyl esters	Yang, Dan; Ding, Shixuan; Huang, Jianhui; et al.	Chemical Communications	49
2013	Isoquinoline N-Oxide Synthesis under Pd-Catalysed C-H Activation/Annulation Processes	Li, Bingyao; Jiao, Pingxuan; Zhong, Hongban; et al.	Synlett	24
2013	Efficient Synthesis of Hydroxyl Isoindolones by a Pd-Mediated C-H Activation/Annulation Reaction	Yu, Qingzhen; Zhang, Nana; Huang, Jianhui; et al.	Chemistry-a European Journal	19
2013	A practical one-pot procedure for the synthesis of N-H isoquinolones	Lu, Shaonan; Lin, Yingfu; Zhong, Hongban; et al.	Tetrahedron Letters	54
2015	Modular synthesis of dihydro-isoquinolines: palladium-catalyzed sequential C(sp(2))-H and C(sp(3))-H bond activation	Liu, W. D.; Yu, Q. Z.; Hu, L. A.; et al.	Chemical Science	6
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Jianhui Huang——Professor

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