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Jie Zhao——Student Counselor (Graduate students)

Nationality:
中国
Phone:
+86-17320298198
Email:
yxyzhaojie@tju.edu.cn
Office:
24-A-210, 92 Weijin Road, Nankai District, Tianjin
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2018-2022 Ph. D. Applied Chemistry (DMPK) Tianjin University
2016-2022 M.S. Pharmacy Tianjin University
2012-2016 Bachelor Pharmacy Tianjin University
Professional Experience
2023-2025 Postdoctoral Shanghai Institute of Materia and Medicia, Chinese Academy of Sciences
Research Area

1. Study the binding site and binding mechanism of stroke new drugs with rat plasma protein by using mass spectrometry and proteomics technology

2. Study the mass balance, pharmacokinetics, and metabolic pathways of innovative drugs in rats and humans by using radioactive labeling technology

3. Study the effects of orphan metabolic enzymes-CYP3A43 on drug metabolism, including CYP3A family enzymes, CYP3A43 mutants, and UGT enzymes on the metabolism of antipsychotic drugs



Honors and Awards
2019-2020 DAAD scholarship, Free University of Berlin, Germany
Patents
Highlighted Publications
1. Jie Zhao, Yuandong Zheng, Peng Lei, Yuying Zhang, Pingping Zhang, Ye Liu, Xingxing Diao, (2025). Characterization of the specific proteins to which HH-A, a drug that alleviates ischemic brain injury, binds in rat plasma. Drug Metabolism and Disposition. Accepted.
2. Jie Zhao, Tao Hu, Hualing Pan, Shu Yan, Mengting Jia, Hua Zhang, Rong Deng, H. Eric Xu, Liyan Miao, Xingxing Diao (2025). Pharmacokinetics, mass balance, and metabolism of [14C]CS0159, a novel Farnesoid X Receptor agonist in humans. In Preparation.
3. Zhao J, Liu S, Wolf C A, Wolber G, Parr M K, Bureik M. (2022). Changes in alprazolam metabolism by CYP3A43 mutants. Biomedicines. 10(12), 3022.
4. Zhao J, Zhang X, Wang Y, Huang H, Sharma S, Sharma S S, Wolf C A, Liu S, Wolber G, Sorensen E J, Bureik M. (2023). Exploring the chemical space of proluciferins as probe substrates for human cytochrome P450 enzymes. Appl Biochem Biotechnol. 195(2):1042-1058.
5. Zhao J, Machalz D, Liu S, Wolf CA, Wolber G, Parr MK, Bureik M. (2022). Metabolism of the antipsychotic drug olanzapine by CYP3A43. Xenobiotica. 52(4), 413-425.
ResearcherID Publications
Year Title Author(s) Source Volume