The research my group lies at the interaction of virus and host proteins, such as the interaction of accessory protein of HIV-1,HIV-2 and SIV with host protein of E3 ligase,SAMHD1 and so on, another study is about molecular epidemiology of virus, including Enterovirus 71A and Coxsackievirus A16.

1.A novel motif  in Vpx and Vpr of HIV/SIV was identified which is critical for Vpx-mediated degradation of nuclear SAMHD1 and Vpr-induced G2 arrest.

2.In the study of circulating HFMD-Associated Coxsackievirus A16, we found that it is genetically and phenotypically distinct from the prototype CV-A16.

3.Map the founction region of host protein SAMHD1 which is critical for nuclear localization and Vpx-Mediated degradation.