TJU HEALTH SCIENCES PLATFORM

Introduction

Zhi Lin ——Professor
Nationality:	China
Phone:
Email:	linzhi@linzhi.net
Office:	Building 15, Tianjin University
School:	School of Life Sciences
ResearcherID:	B-1254-2016
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Education Experience

1994-1998	Bachelor of Science Biotechnology	Xiamen University
1998-2001	M.S. Biochemistry & Molecular Biolology	Xiamen University
2002-2006	Ph. D. Structural Biology	National University of Singapore
2007-2009	Postdoctoral Structural Biology	National University of Singapore

Professional Experience

2006-2007	Research Assistant	National University of Singapore
2009-2012	Research Fellow	National University of Singapore
2012-2015	Senior Research Fellow	National University of Singapore
2015-2016	Principle Investigator	Tianjin University
2011-2016	Visiting Professor	Ningxia Medical School
2015-2016	Visiting Senior Research Fellow	National University of Singapore

Research Area

1. Bioengineering of spider fibroins

Spider silks are proteinaceous biopolymers with extraordinary physical properties and biomimetic potential. This research focuses on the structure-based engineering and design of silk fibroins for the production of artificial spider silks with desirable mechanical properties.

2. NMR structural & functional studies on p75NTR signaling

p75 neurotrophin receptor (p75NTR) is a member of the Tumor Necreosis Factor Superfamily and its signaling actively contributes to neurodegeneration. The aim of this project is to elucidate structural mechanisms of p75NTR signaling in the nervous system and to discover drugs for neurodegenerative diseases and nerve injury.

Honors and Awards

Peiyang Scholar (O plan), Tianjin University

Chunhui Scholar, MOE, China, 2010-2012

Singapore Millennium Foundation Scholarship, Singapore 2007-2009

Excellent Graduate (Honor Title), Xiamen University, 1998

Patents

Nill

Highlighted Publications

Lin, Z., Xu, Y., Yang, S., and Yang, D. (2006). Sequence-specific assignment of aromatic resonances of uniformly 13C,15N-labeled proteins by using 13C- and 15N-edited NOESY spectra. Angew. Chem. Int. Ed. 45:1960-1963.

Lin, Z., Sriskanthadevan, S., Huang, H., Siu, C.H., and Yang, D. (2006). Solution structures of the adhesion molecule DdCAD-1 reveal new insights into Ca(2+)-dependent cell-cell adhesion. Nat Struct Mol Biol 13:1016-1022.

Lin, Z., Huang, W., Zhang, J., Fan, J.S., and Yang, D. (2009). Solution structure of eggcase silk protein and its implications for silk fiber formation. Proc Natl Acad Sci USA 106:8906-8911.

Lin, Z., Deng, Q., Liu, X.Y., and Yang, D. (2013). Engineered large spider eggcase silk protein for strong artificial fibers. Adv Mater 25:1216-1220.

Lin, Z., Tann, J.Y., Goh, E.T., Kelly, C., Lim, K.B., Gao, J.F., and Ibanez, C.F. (2015). Structural basis of death domain signaling in the p75 neurotrophin receptor. eLife 4:e11692

ResearcherID Publications

Year	Title	Author(s)	Source	Volume

Zhi Lin ——Professor

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