The research in the group of Zhou encompasses three main areas, including, 1) Investigation of molecular pathogenesis of diseases and cell signaling pathways, and pharmacological mechanism of drug action, 2) Development of new small molecule based targeting anticancer drugs, e.g., TRAF6 as a new target of anti-tumor therapy, 3) Development of cells and C. elegans models, for high-throughput screenings, e.g., anti-aging drugs.