The research of the Bao group involves 1) development of new analytical technologies, such as (a) wide bore electrophoresis (WBE), which increases sample loading significantly compared to capillary electrophoresis (CE) for better detection and easy interface with MS and other technologies;(b) WBE containing microchip systems; and (c) multi-dimensional separation systems; 2)development of innovative bio/analytical methods such as affinity CE and liquid phase microextraction (LPME) for proteomics and pharmaceutical analysis; 3) development of new separation media including various silica gel, polymeric resin, and even agarose gel based resins and their applications; and 4)new development of miniaturized and high throughput sample preparation techniques, such as fritless SPE, membraneSPE, supported liquid extraction (SLE) and fast protein precipitation, etc.