1.  Using imaging techniques, as well as electron microscopy, X-ray crystallography, NMR spectroscopy to understand the molecular mechanisms of activities of macromolecules at high-resolution level.

2.  Using biophysical and biochemical techniques to investigate the interactions between the macromolecules.

3.  High-throughput screening the binding of ligand-receptor and compound-drug target.

4.  Structure-based rational drug design.