The goal of The Optical Probe and Imaging for Cell Functions Platform is to encourage collaborative research effort to develop biochemical-, cell-, and high-content based assays and training amenable to high-throughput screening of chemical compounds or small molecule libraries on live cells. One of the core missions of the Optical Probe and Imaging Platform is the custom development of new fluorescent probes and fluorescence-based biological assays including:
·Characterization and quantification of fluorescent probe absorption spectra, extending into the increasingly-important near-infrared range (NIR).
·Characterization of fluorescent probe steady-state emission into the NIR.
·Quantification of fluorescent probes lifetimes into the NIR, allowing the development of lifetime-based assays to complement intensity-based assays.
·Development of protein- and membrane-binding assays with individual proteins, micelles, or whole cells, based on fluorescence anisotropy.
Another core mission is high-content screening (HCS). The development of fluorescent probes and cell-based assays allows us to perform high-content screening (HCS) in cell-based systems using living cells as tools in biological research to elucidate the cell signaling pathways and functions of normal and diseased cells. HCS can also be used to discover and optimizes new drug candidates. High content screening is a combination of modern cell biology, with all its molecular tools, with automated high resolution microscopy and robotic handling.
High Content Screening System can provide:
·Ultra-fast image acquisition and powerful data processing capabilities translate into immediate results
·Exceptional image quality even at highest speed for more reliable data and more confidence.
·Supports the complete spectrum of HCS applications, from the simplest to the most sophisticated. Tailor a system that's exactly right for the needs of each lab, and easily reconfigure to meet changing requirements.
Rapid online image data processing and thoroughly flexible analysis for all high content cellular applications, including multi-parametric multiplex assays.
The goal of The Optical Probe and Imaging for Cell Functions Platform is to encourage collaborative research effort to develop biochemical-, cell-, and high-content based assays and training amenable to high-throughput screening of chemical compounds or small molecule libraries on live cells. One of the core missions of the Optical Probe and Imaging Platform is the custom development of new fluorescent probes and fluorescence-based biological assays including:
·Characterization and quantification of fluorescent probe absorption spectra, extending into the increasingly-important near-infrared range (NIR).
·Characterization of fluorescent probe steady-state emission into the NIR.
·Quantification of fluorescent probes lifetimes into the NIR, allowing the development of lifetime-based assays to complement intensity-based assays.
·Development of protein- and membrane-binding assays with individual proteins, micelles, or whole cells, based on fluorescence anisotropy.
Another core mission is high-content screening (HCS). The development of fluorescent probes and cell-based assays allows us to perform high-content screening (HCS) in cell-based systems using living cells as tools in biological research to elucidate the cell signaling pathways and functions of normal and diseased cells. HCS can also be used to discover and optimizes new drug candidates. High content screening is a combination of modern cell biology, with all its molecular tools, with automated high resolution microscopy and robotic handling.
High Content Screening System can provide:
·Ultra-fast image acquisition and powerful data processing capabilities translate into immediate results
·Exceptional image quality even at highest speed for more reliable data and more confidence.
·Supports the complete spectrum of HCS applications, from the simplest to the most sophisticated. Tailor a system that's exactly right for the needs of each lab, and easily reconfigure to meet changing requirements.
Rapid online image data processing and thoroughly flexible analysis for all high content cellular applications, including multi-parametric multiplex assays.
