TJU HEALTH SCIENCES PLATFORM

Introduction

Hyun Min Kim——Associate Professor
Nationality:	Republic of Korea
Phone:
Email:	HKim@tju.edu.cn
Office:	Lab 413 Building 24
School:	School of Pharmaceutical Science and Technology
ResearcherID:	K-7179-2013
Group weblink
	http://KimLab.website2.me/

Education Experience

2009-2016	Postdoctoral Genetics	Harvard Medical School, U.S.A
2003-2009	Ph. D. Molecular Genetics	Georgia Institude of Technology, U.S.A

Professional Experience

2009-2016	Research fellow	Harvard Medical School, U.S.A
2004-2009	Research and Teaching assistant	Georgia Institute of Technology, U.S.A

Research Area

We are interested in understanding the DNA repair mechanism in the germline. Especially, we have focused on investigating the epigenetic regulation of DNA damage response and repair. We use a microscopic size nematode C. elegans and mammalian cells to study epigenetic control of DNA repair mechanism. 1. The role of conserved Epigenetic regulators in DNA repair and damage response. 2.The role of novel and conserved gene of DNA repair and damage response.

We are recuiting hard working students. Post-doc or Students interested in working in Genetics or Molecular biology in my lab, send an E-mail to hm.k @ duke.edu

Honors and Awards

National Natural Science Foundation of China, General Grant (No 31972876), Year 2020-2023. Research title: Mechanism of the new histone demethylase LSD1/2 homologs function in DNA damage repair.

Scholarship from Keystone Symposia on Molecular and Cellular Biology, March 1 2009.

Graduate research mentor award for Undergraduate Research Scholar, Georgia Tech/Emory Center for the Engineering of Living Tissue, 2009.

Sarstedt® Graduate Student Award for ‘Outstanding Accomplishments in Ph.D. research’, Dec 11 2008, Sandi Battista, Sarstedt, Inc.

Travel award from research mentor for Research Experience for Undergraduates 2007-2008.

Outstanding research paper of year 2001, Dec 2001, CR association, Korea.

Patents

Highlighted Publications

Xiaojuan Zhang, Sisi Tian, Sara E. Beese-Sims, Jingjie Chen, Nara Shin, Monica P. Colaiácovo and Hyun-Min Kim*. Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. PLOS Genetics. 2021 Jul 30;17(7):e1009715. doi: 10.1371/journal.pgen.1009715.

Kim HM*, Zhang X. (2021) Design of Repair Templates for CRISPR-Cas9-Triggered Homologous Recombination in Caenorhabditis elegans. In: Islam M.T., Molla K.A. (eds) CRISPR-Cas Methods. Springer Nature. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1657-4_24

Hyun-Min Kim*, Tian Sisi and Shouyue Wang. An affordable plasmid miniprep suitable for proficient microinjection in Caenorhabditis elegans. 3 BIOTECH 10, 350 (2020). https://doi.org/10.1007/s13205-020-02346-7.

Kim, H.-M., & Colaiácovo, M. P. (2019). CRISPR-Cas9-guided genome engineering in caenorhabditis elegans. Current Protocols in Molecular Biology, Sept 24 129, e106. doi: 10.1002/cpmb.106

Hyun-Min Kim, Sara Beese-Sims and Monica Colaiácovo: Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 in C. elegans. GENETICS/2018/300823R1. # Highlighted paper by Genetics Society of America.2018 June.

Nottke AC, Kim HM, Colaiácovo MP. Wrestling with Chromosomes: The Roles of SUMO During Meiosis. Adv Exp Med Biol. 2017;963:185-196. doi: 10.1007/978-3-319-50044-7_11.

Kim HM and Colaiácovo MP. CRISPR-Cas9-guided Genome Engineering in C. elegans. Current Protocols in Molecular Biology, 2016 July. http://onlinelibrary.wiley.com/doi/10.1002/cpmb.7/full

Norris AD*, Kim HM*, Colaiácovo MP and Calarco JA. Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual Marker Selection Cassettes. 2015 Aug. GENETICS. (*Co-first author)

Kim HM# and Colaiácovo MP#. DNA damage sensitivity assays in Caenorhabditis elegans. Bio-protocol (ISSN: 2331-8325), 2015 Mar. (#Co-correspondence)

Kim HM and Colaiácovo MP. New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. GENETICS. 2015 Jun;200(2):495-504.

Kim HM and Colaiácovo MP.ZTF-8 interacts with the9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. PLOS Genetics,2014Oct 10(10):e1004723.

Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. ‘REST and stress resistance in ageing and Alzheimer's disease’, NATURE, 2014 Mar 27;507(7493):448-54.

Kim HM, Narayanan V, Mieczkowski PA, Petes TD, Krasilnikova MM, Mirkin SM and Lobachev KS, 'Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair', EMBO JOURNAL, Nov 2008, vol.27,pp.2896-906

Narayanan V, Mieczkowski PA, Kim HM, Petes TD and Lobachev KS, 'The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks', CELL, Jun 2006, vol.125, pp.1283-96

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2014	ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the C. elegans Germline	Kim, H. M.; Colaiacovo, M. P.	PLoS Genet	10
2013	ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans	Sengupta, M. S.; Low, W. Y.; Patterson, J. R.; et al.	J Cell Sci	126
2013	Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis	Saito, T. T.; Lui, D. Y.; Kim, H. M.; et al.	PLoS Genet	9
2012	Modulation of mutagenesis in eukaryotes by DNA replication fork dynamics and quality of nucleotide pools	Waisertreiger, I. S.; Liston, V. G.; Menezes, M. R.; et al.	Environ Mol Mutagen	53
2012	Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells	Oh, B.; Kim, T. Y.; Min, H. J.; et al.	Anticancer Drugs	24
2011	Friedreich’s ataxia (GAA)n*(TTC)n repeats strongly stimulate mitotic crossovers in Saccharomyces cerevisae	Tang, W.; Dominska, M.; Greenwell, P. W.; et al.	PLoS Genet	7
2008	Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair	Kim, H. M.; Narayanan, V.; Mieczkowski, P. A.; et al.	EMBO J	27
2006	The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks	Narayanan, V.; Mieczkowski, P. A.; Kim, H. M.; et al.	Cell	125
2001	Sequence analysis and insertional inactivation of a gene encoding Moraxella sp. CK-1 cell wall hydrolase	Kim, H. M.; Ohn, T. B.; Min, B. R.; et al.	Antonie Van Leeuwenhoek	79
19条记录,2 / 2 页 1 2

Hyun Min Kim——Associate Professor

Useful Links