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Juan Wang——Professor

Nationality:
CHINA
Phone:
022-87401830
Email:
drwangjuan@tju.edu.cn
Office:
Room C514/A403, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2009-2012 Ph. D. Applied chemistry Tianjin University, CN
Professional Experience
2012-2018 Lecture Tianjin University
2018-2024 Associate professor Tianjin university
2024- Professor Tianjin University
Research Area

Wang’s research addresses production of traditional Chinese medicine (TCM) active compounds through biotechnology. 1. Analysis of TCM active compounds biosynthesis pathway. 2. Studies on TCM active compounds metabolism regulation. 3. Large scale tissue culture of TCM active compounds.


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Honors and Awards
Research team of 2015, SPST, Tianjin university
2017 Outstanding Master Thesis Supervisor Award
2018 Beiyang young talent
2019年国家科技进步2等奖。雪莲、人参等药用植物细胞和不定根培养及产业化关键技术。
Patents
高文远,王娟,姚陆等. 具有抑制凝血酶活性的药物组合物及其用途. CN201910839904.6
高文远,王娟,姚陆等. 人参PgWRKY4X转录因子在调控人参中人参皂苷类化合物含量的应用. CN202010129213.X
高文远,李建丽,王娟,李静,李金鑫,刘书杰. 一种提高甘草不定根中黄酮化合物含量的组培方法. CN20151076169.X
高文远,王娟,李金鑫,李静,李建丽,刘书杰. 采用两种诱导子促进人参不定根中皂苷积累的方法. CN201510254483
高文远; 李静; 王娟. 三七细胞悬浮培养的方法. CN201410113439.5
高文远; 王娟; 李金鑫; 李静; 李建丽; 刘书杰. 三七不定根的诱导及组织培养方法. CN201510075978
Highlighted Publications
Yaowu Su, Wenqi Yang, Rubing Wang, Huanyu Zhang, Jie Meng, Hongyan Jing, Guoqi Zhang, Juan Wang*, Lanping Guo*, Wenyuan Gao*. ZnO-S.cerevisiae: An effective growth promoter of Astragalus memeranaceus and nano-antifungal agent against Fusarium oxysporum. Chemical Engineering Journal 486 (2024) 149958
Rubing Wang#, Yaowu Su#, Wenqi Yang, Huanyu Zhang, Juan Wang*, Wenyuan Gao*. Enhanced precision and efficiency in metabolic regulation: Compartmentalized metabolic engineering. Bioresource Technology 402, 130786 (2024) 130786
Lu Yao#, Huanyu Zhang#, Yirong Liu, Qiushuang Ji, Jing Xie, Ru Zhang, Luqi Huang, Kunrong Mei*, Juan Wang*, Wenyuan Gao*. Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis. Journal of integrative plant biology. 2022
Lu Yao, Juan Wang*, Junping He, Luqi Huang*, Wenyuan Gao*. Endophytes, Biotransforming Microorganisms, and Engineering Microbial Factories for Production of Triterpenoid Saponins. Critical reviews in biotechnology. 2021, 41(2): 249-272
Lu Yao#, Juan Wang#, Jiachen Sun, Junping He, Kee-Yoeup Paek, So-Young Park, Luqi Huang, Wenyuan Gao. A WRKY transcription factor, PgWRKY4X, positively regulates ginsenoside biosynthesis by activating squalene epoxidase transcription in Panax ginseng. Industrial crops and products. 154 (2020) 112671
Lu Yao, Shihui Wang, Wenxia Liang, Juan Wang*, Wenyuan Gao*. Screening and evaluation of adventitious root lines of Panax notoginseng by morphology, gene expression, and metabolite profiles. Applied Microbiology and Biotechnology, 2019,103(11): 4405~4415
Shihui Wang#, Juan Wang#, Wenxia Liang, Lu Yao, Wenyuan Gao. Promotion of ginsenosides production in a co-cultivation system of Panax ginseng adventitious roots and immobilized Aspergillus niger. Industrial crops and products. (2019) 140: 111564
Jun Lu, Lu Yao, Jin-Xin Li, Shu-Jie Liu, Yan-Ying Hu, Shi-Hui Wang, Wen-Xia Liang, Lu-Qi Huang, Yu-Jie Dai, Juan Wang*, and Wen-Yuan Gao. Characterization of UDP-Glycosyltransferase Involved in Biosynthesis of Ginsenosides Rg1 and Rb1 and Identification of Critical Conserved Amino Acid Residues for Its Function. J. Agric. Food Chem. 2018, 66, 9446−9455
J Wang*, JL Li, J Li, JX Li, SJ Liu, WY Gao*. LSP1, a responsive protein from Meyerozyma guilliermondii, elicits defence response and improves glycyrrhizic acid biosynthesis in Glycyrrhiza uralensis Fisch adventitious roots. Journal of Cellular Physiology. 2017, 232: 3510–3519
Juan Wang*, Jin-Xin Li, Jian-Li Li, Shu-Jie Liu, Xiao-Lei Wu, Jing Li and Wenyuan Gao*. Transcriptome profiling shows gene regulation patterns in ginsenoside pathway in response to methyl jasmonate in Panax Quinquefolium adventitious root. Scientific Reports. 2016, 6: 37263
JX Li, SJ Liu, J Wang*, J Li, DH Liu, JL Li, WY Gao*. Fungal elicitors enhance ginsenosides biosynthesis, expression of functional genes as well as signal molecules accumulation in adventitious roots of Panax ginseng C. A. Meyer. Journal of Biotechnology. 2016, 239: 106–114
JL. Li, J. Wang*, J. Li, J.X. Li, S.J. Liu, W.Y. Gao*. Protein elicitor isolated from Escherichia coli induced bioactive compound biosynthesis as well as gene expression in Glycyrrhiza uralensis Fisch adventitious roots. RSC Advances. 2016, 6, 111622–111631
ResearcherID Publications
Year Title Author(s) Source Volume
2015 HPLC-ESI-MSn Analysis, Fed-Batch Cultivation Enhances Bioactive Compound Biosynthesis and Immune-Regulative Effect of Adventitious Roots in Pseudostellaria heterophylla Wang, Juan; Li, Jing; Li, Hongfa; et al. Applied Biochemistry and Biotechnology 177
2015 Influence of step-wise aeration treatment on biomass and bioactive compounds of Panax ginseng adventitious root in balloon-type bubble bioreactor Wang, Juan; Gao, Wenyuan; Wang, Qin; et al. Research on Chemical Intermediates 41
2015 Optimization of balloon-type bubble bioreactor angle and methyl jasmonate concentration to enhance metabolite production in adventitious roots of Pseudostellaria heterophylla Wang, Qin; Wang, Juan; Chai, Hongyan; et al. Research on Chemical Intermediates 41
2014 Optimization and quality assessment of adventitious roots culture in Panax quinquefolium L. Liu, Hui; Wang, Juan; Gao, Wenyuan; et al. Acta Physiologiae Plantarum 36
2013 Cluster analysis of ginseng tissue cultures, dynamic change of growth, total saponins, specific oxygen uptake rate in bioreactor and immuno-regulative effect of ginseng adventitious root Wang, Juan; Man, Shuli; Gao, Wenyuan; et al. Industrial Crops and Products 41
2013 Comparison of ginsenoside composition in native roots and cultured callus cells of Panax quinquefolium L. Wang, Juan; Liu, Hui; Gao, Wen-Yuan; et al. Acta Physiologiae Plantarum 35
2013 Effect of methyl jasmonate on the ginsenoside content of Panax ginseng adventitious root cultures and on the genes involved in triterpene biosynthesis Wang, Juan; Gao, Wenyuan; Zuo, Beimei; et al. Research on Chemical Intermediates 39
2013 Establishment and Quality Assessment of Tissue Cultures in Glycyrrhiza uralensis Fisch. Wang, Juan; Gao, Wenyuan; Zhang, Liming; et al. Applied Biochemistry and Biotechnology 169
2013 Identification of triterpenoids and flavonoids, step-wise aeration treatment as well as antioxidant capacity of Glycyrrhiza uralensis Fisch cell Wang, Juan; Zhang, Jian; Gao, Wenyuan; et al. Industrial Crops and Products 49
2012 Advances in study of ginsenoside biosynthesis pathway in Panax ginseng C. A. Meyer Wang, Juan; Gao, Wen-Yuan; Zhang, Jian; et al. Acta Physiologiae Plantarum 34
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