TJU HEALTH SCIENCES PLATFORM

Introduction

Chang Chung——Professor
Nationality:	USA
Phone:	022-27401105
Email:	cychung@tju.edu.cn
Office:	Room A304, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	G-7522-2012
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Education Experience

1990-1995	Ph. D.	Duke University, NC, USA
1995-1997	Postdoctoral	University of California, San Diego, USA

Professional Experience

1996-1998	Teaching Assistant	Seoul National University, Seoul, Korea
1991-1994	Research Assistant	Duke University, Durham, NC USA
1995-1997	Postdoctoral Fellow	UC-San Diego, San Diego, CA USA
1997-2001	Assistant Project Scientist	UCSD
2001-2009	Assistant Professor	Vanderbilt University Medical Center
2005-2014	Faculty Fellow	Biosystems Research and Education
2009-2014	Associate Professor with tenure	Vanderbilt University Medical Center
2015-	Professor	Tianjin University

Research Area

The research in the Chung group focuses on understanding the role of microglia in neuroinflammation. Inflammation is a key component of pathophysiology of both acute injuries and chronic diseases including Parkinson’s and Alzheimer’s. Microglia activation/chemotaxis is prerequisite for microglia function whether neuroprotective or inflammatory, making understanding essential for design of rational approaches for therapeutic modulation and regulation of microglia proliferation and chemotaxis. Emphasis is on control of activation/chemotaxis of resident microglia in the brain in early stages of neuroinflammation. Unraveling complex networks of signaling downstream of P2Y12 receptor during microglia chemotaxis is an important target. Elucidation of neurotoxic effects of microglia observed in depression is another area of research interests.

Honors and Awards

Kyemong Fellowship: 1982-1986

Ministry of Education Grant-in-Aid of Research: 1986-1988

American Society of Cell Biology Student Travel Award: 1994

Duke University Graduate School Fellowship: 1990 - 1995

Special Fellow Award from the Leukemia and Lymphoma Society 2000-2003

NIH/NIGMS (RO1 GM068097), Principal Investigator: Chang Chung, 2003 – 2014

American Heart Association Grant-in-Aid (0655167B): Principal Investigator: Chang Chung, 2006 – 2008

Teaching Award, SPST, Tianjin University, 2015

Patents

Wikswo, John P.; Baudenbacher, Franz J.; Prokop, Ales; LeBoeuf, Eugene; Chung, Chang Y.; Cliffel, David E.; Haselton, Frederick R.; Hofmeister, William H.; Lin, Charles P.; McCawley, Lisa J.; Reiserer, Randall S.; and Stremler, Mark A., to Vanderbilt University. Capillary perfused bioreactors with multiple chambers 08003378 Cl. 435-289.1.

Highlighted Publications

Lee, S. and C.Y. Chung (2009). Role of VASP phophorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation. Molecular Cellular Neuroscience 42:382-390

Yang Fan, Zhilu Chen, Janak Pathak, Ana Carneiro, and Chang Y. Chung (2018). Differential Regulation of Adhesion and Phagocytosis of Resting and Activated Microglia by Dopamine. Front. Cell. Neurosci. 12:309

Sang-Hyun Lee, Neetu Sud, Narae Lee, Chang Y. Chung (2016). Regulation of Integrin a6 Recycling by iPLA2 to Promote Microglia Chemotaxis on Laminin. J. Biol. Chem. 291:23645-23653

Lee, S.-H.; Hollingsworth, R.; Kwon, H.-Y.; Chung, C.-Y. (2012) β-Arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser83 and microglia chemotaxis. Glia 60, 1366.

Lee, S.; Schneider, C.; Higdon, A. N.; Darley-Usmar , V. M.; Chung, C. Y. (2011) Role of iPLA2 in the regulation of Src trafficking and microglia chemotaxis. Traffic 12, 878.

Myers, S.; Han, J.; Lee, Y.; Firtel, R. A.; Chung, C. Y. (2005) A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis. Mol. Biol. Cell 16, 2191.

Chung, C. Y.; Potikyan, G.; Firtel, R. A. (2001) Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. Mol. Cell 7, 937.

Chung, C.; Reddy, T. B. K.; Zhou, K.; Firtel, R. A. (1998) A novel, putative MEK kinase controls developmental timing and spatial patterning in Dictyostelium and is regulated by ubiquitin-mediated protein degradation. Genes Devel. 12, 3564.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2013	RacC is required for the vesicular trafficking of ACA and streaming of Dictyostelium cells.	Wang, C.; Cao, Z.; Jung, D.; et al.	Molecular Biology of the Cell	24
2012	beta-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis	Lee, Sang-Hyun; Hollingsworth, Ryan; Kwon, Hyeok-Yil; et al.	Glia	60
2012	Role of iPLA2 in the regulation of the endosomal recycling of integrin and chemotactic motility of microglia	Lee, S-H.; Sud, N.; Lee, N.; et al.	Molecular Biology of the Cell	23
2011	Alteration of alpha 6 integrin expression and chemotactic motility of microglia upon ADP stimulation.	Lee, S-H.; Chung, C. Y.	Molecular Biology of the Cell	22
2011	Role of iPLA(2) in the Regulation of Src Trafficking and Microglia Chemotaxis	Lee, Sang-Hyun; Schneider, Claus; Higdon, Ashlee N.; et al.	Traffic	12
2010	Bimodal Analysis Reveals a General Scaling Law Governing Nondirected and Chemotactic Cell Motility	Gruver, J. Scott; Potdar, Alka A.; Jeon, Junhwan; et al.	Biophysical Journal	99
2010	Functional Roles of VASP Phosphorylation in the Regulation of Chemotaxis and Osmotic Stress Response	Lin, Wan-Hsin; Nelson, Sharon E.; Hollingsworth, Ryan J.; et al.	Cytoskeleton	67
2009	Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis	Lee, S.; Han, J. W.; Leeper, L.; et al.	Biochimica Et Biophysica Acta-Molecular Cell Research	1793
2009	Role of VASP phosphorylation for the regulation of microglia chemotaxis via the regulation of focal adhesion formation/maturation	Lee, S.; Chung, C. Y.	Molecular and Cellular Neuroscience	42
2008	3 ’-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis	Gruver, J. S.; Wikswo, J. P.; Chung, C. Y.	Biophysical Journal	95
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Chang Chung——Professor

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