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Robert P. Borris ——
Nationality:
USA
Phone:
183-02242039
Email:
rborris@tju.edu.cn
Office:
Room A206, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
K-1095-2015
Group weblink
Education Experience
1970-1974 Bachelor of Science Biology Loyola University, Chicago, USA
1975-1977 Bachelor of Science Pharmacy University of Illinois Medical Center, Chicago, US
1977-1981 Doctor of Philosophy Pharmacognosy University of Illinois Medical Center, Chicago, US
1981-1982 Postdoctoral Natural Products Chemistry University of Zuruich, Zurich, CH
Professional Experience
2007-2013 Associate Dean for Research and Associate Professo College of Phaermacy, University of Hawaii at Hilo
2007-2007 Vice President, Botanical Science and Regulation Council for Responsible Nutrition
2001-2005 Senior Investigator Merck Research Laboratories, Dept of Natural Products Chemistry
1993-2000 Senior Research Fellow Merck Research Laboratories, Dept. of Natural Products Chemistry
1987-1993 Research Fellow Merck Research Laboratories, Dept. of Natural Products Chemistry
1983-1987 Senior Research Chemist Merck Research Laboratories, Dept. of Natural Products Chemistry
1982-1983 Assistant Professor of Pharmacogbnosy Rutgers University
1978-1980 Registered Pharmacist Meyer Drugs, Chicago
2014- Professor Tianjin university
Research Area

The research of the Borris groups involves a) Validation of traditional medical practices, b) Discovery of novel biologically active natural products, c) Natural products used as dietary supplements, d) Phytochemical systematics, e) Application of NMR spectrometry to the structure determination of natural products, and f) Applications of high performance centrifugal partition chromatography to the isolation of biologically active natural products and other organic compounds.

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Honors and Awards
National Merit Scholarship (USA) 1970 - 1974
Illinois State Scholarship 1970 - 1974
Phi Sigma Tau Honor Society
Rho Chi Pharmaceutical Honor Society
Phi Kappa Phi Honor Society
American Foundation for Pharmaceutical Education Fellowship 1979 - 1981
Dorothea H. Fleming Student Research Fellowship 1980 - 1981.
Helmut Legerlotz Postdoctoral Research Fellowship 1981 - 1982.
Fellow, Linnean Society of London (elected 1995)
President, American Society of Pharmacognosy 1997-1998
Board of Directors, Institute for Triple Helix Innovation, Honolulu, HI, 2009 - 2013
Patents
Monaghan, R. L., Sigal, N. H., Kaplan, L., Byrne, K. M., Borris, R. P., Dumont, F. J., Garrity, G. M., and Zink, D. L.(1989) Fermentation of Novel Immunosuppressant Agents by Streptomyces hygroscopicus ascomyceticus. European Patent EP 323,865.
Borris, R. P., Burg, R. W., Hensens, O. D., Huang, L., Kelemen, L., and Mochales, S. (1989) Manufacture of Sterol Inhibitors of Testosterone 5-Alpha Reductase with Gliocladium. U. S. Patent 4,814,324.
Borris, R. P., Wicker, L. S., Zink, D. L., and Lien, T. H. (1990) Novel Immunosuppressant Compound. European Patent EP 358,508
Borris, R. P., Lam, Y. K. T., and Koupal, L. (1993). Preparation of Antimigraine Alkyl Indole Derivative with Penicillium daleae. U.S. Patent 5,233,050.
Kaplan, L., Borris, R. P., Byrne, K. M., Wicker, L. S., and Zink, D. L. (1995) Microbial Immunoregulant. U.S. Patent 5,431,896
Kaplan, L., Borris, R. P., Byrne, K. M., Wicker, L. S., and Zink, D. L. (1995) Immunosuppressant L-687819 and its manufacture with Streptomyces. European Patent EP 388,153
Highlighted Publications
Lange, I., Moschny, J., Tamanyan, K., Khutsishvili, M., Atha, D., Borris, R.P., and Koomoa, D.L. Scrophularia orientalis Extract Induces Calcium Signaling and Apoptosis in Neuroblastoma Cells. Int. J. Oncology, 2016, 48, 1608-1616.
Showman, A., Baker, J.D., Linares, C., Naeole, C.K., Borris, R.P., Johnston, E., Konanui, J., and Turner, H. Contemporary Pacific and Western Perspectives on ‘Awa Toxicology. Fitoterapia, 2015, 100, 56-67.
Lange, I., Moschny, J., Kerimov, V.M., Khutsishvili, M. Atha, D., Borris, R.P., and Koomoa, D.L. Juniper extracts regulate calcium signaling pathways and induce apoptosis in neuroblastoma cells. J. Pharm. Pharm.Scien. 2015, 1 (1) 1-7.
Clark, B.R., Pramanick, S., Arancon, N., and Borris, R.P. Unusual Flavonoid Glycosides from the Hawaiian Tree Metrosideros polymorpha. Nat. Prod. Commun., 2015, 10 (6) 925-928.
Shimoda, L.M.N., Showman, A., Baker, J.D., Lange, I., Koomoa-Lange, D., Borris, R.P., and Turner, H. Differential Regulation of Calcium Signaling Pathways by Components of Piper methysticum (‘Awa) Phytotherapy Research, 2014, 29, 582-590.
Clark, B.R., Bliss, B.J., Suzuki, J.Y., and Borris, R.P. Chemotaxonomy of Hawaiian Anthurium Cultivars Based on Multivariate Analysis of Phenolic Components. J. Agric. Food Chem. 2014, 62(46) 11323-11334.
Ul-Haq, I.; Youn, U.-J.; Chai, X.-Y.; Park, E. J.; Kondratyuk, T. P.; Simmons, C. J.; Borris, R. P.; Mirza, B.; Pezzuto, J. M.; Chang, L. C. Biologically active Withanolides from Withania coagulans. J. Nat. Prod. 2013, 76, 22.
Youn, U.-J.; Park, E.-J.; Kondratyuk, T. P.; Simmons, C. J.;Borris, R. P.; Tanamatayarat, P.; Wongwiwatthananukit, S.; Toyama, O.; Songsak, T.; Pezzuto, J. M.; Chang, L. C. Anti-inflammatory Sesquiterpene Lactones from the Flower of Vernonia cinerea. Bioorg. Med. Chem. Lett. 2012, 22, 5559.
Clark, B. R.; Suzuki, J. Y.; Bliss, B. R.; and Borris, R. P. Flavone C-glycosides from Anthurium andreanum. Nat. Prod. Commun. 2012, 7, 747.
Jayasuriya, H.; Herath, K. B.; Ondeyka, J. G.; Guan, Z.; Borris, R. P.; Tiwari, S.; de Jong, W.; Chavez, F.; Moss, J.; Stevenson, D. W.; Beck, H. T.; Slattery, M.; Zamora, N.; Schulman, M.; Ali, A.; Sharma, N.; MacNaul, K.; Hayes, N.; Menke, J. G.; Singh, S. B. Diterpenoid, Steroid and Triterpenoid Agonists of Liver X Receptors from Diversified Terrestrial Plants and Marine Sources. J. Nat. Prod. 2005, 68, 1247.
Herath, K.; Jayasuriya, H.; Ondeyka, J. G.; Guan, Z.; Borris, R. P.; Stijfhoorn, E.; Stevenson, D.; Wang, J.; Sharma, N.; MacNaul, K.; Menke, J. G.; Ali, A.; Schulman, M. J.; Singh, S. B. Guttiferone I, a New Prenylated Benzophenone from Garcinia humilis as a Liver X Receptor Ligand. J. Nat. Prod. 2005, 68, 617.
ResearcherID Publications
Year Title Author(s) Source Volume
1985 Traditional Medicinal Plants of Thailand. VI. Isolation of Cryptomeridiol from Blumea balsamifera (Compositae). Ruangrungsi, N.; Tappayuthpijarn, P.; Tantivatana, P.; et al. Journal of the Science Society of Thailand 11
1984 Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana. Borris, R P; Cordell, G A Journal of natural products 47
1984 The Structure of Melinonin-E, A Quaternary Indole Alkaloid from Strychnos melinoniana Baillon (Loganiaceae). Borris, R.P.; Guggisberg, A.; Hesse, M. Helvetica Chimica Acta 67
1983 Chemistry of Acronycine. I.  Carbon-13 NMR Studies on Acronycine and its Derivatives Funayama, S.; Borris, R.P.; Cordell, G.A. Journal of Natural Products 46
1983 Microminutin, a Novel Cytotoxic Coumarin from Micromelum minutum (Rutaceae) Tantivatana, P.; Ruangrungsi, N.; Vaisiriroj, V.; et al. Journal of Organic Chemistry 48
1983 NMR Spectral Analysis of Cadambine from Anthocephalus cadamba. Handa, S.S.; Borris, R.P.; Cordell, G.A.; et al. Journal of Natural Products 46
1983 Studies on the Uleine Alkaloids. I. Carbon-13 NMR Studies on Uleine, 20 Borris, R.P.; Lankin, D.; Cordell, G.A. Journal of Natural Products 46
1983 Studies on the Uleine Alkaloids. II. Carbon-13 NMR Studies on Uleine Derivatives Lacking the 16,17-Double Bond. Borris, R.P.; Lankin, D.; Cordell, G.A. Journal of Natural Products 46
1983 Studies on the Uleine Alkaloids. III. Chemical and Microbial Transformations of Uleine. Borris, R.P.; Cordell, G.A. Journal of Natural Products 46
1983 The Structure of C-Alkaloid-O, a Constituent of Calabash Curare Borris, R.P.; Guggisberg, A.; Hesse, M. Helvetica Chimica Acta 66

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