TJU HEALTH SCIENCES PLATFORM

Introduction

Lei Chen——Associate Professor
Nationality:	CHINA
Phone:
Email:	chenlei@tju.edu.cn
Office:	Room 412-2, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	K-2114-2015
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Education Experience

2003-2006

Ph. D. Applied Chemistry

Tianjin University, CN

Professional Experience

2006-	Associate Professor	SPST,Tianjin Univ.
2013-2014	Visiting Scholar	UCSB,USA

Research Area

The research of Prof. Chen's group is focused on synthesis of biomaterials and development of modern separation and analysis technology. In particular, efforts include a) Development of mixed-mode chromatography stationary phases according to the structure of analytes. b) Design novel chiral stationary phases to establish “single-column detection technology” to improve the quality control efficiency of chiral drugs, and investigate the chiral separation mechanism by molecular simulation and chiral nuclear magnetic resonance. c) Exploitation of magnetic separation technology in the purification of biological samples. Additionally, efforts are extended towards control the morphology and pore structure of silica microspheres, and to optimize HPLC and LC-MS separation and identification methods for complex samples.

Honors and Awards

Patents

Chen L.,Huo Z.X., Wan Q.H, Micron-scale monodispersed porous silica microsphere and its preparation method. 2022-1-11, Chinese, ZL 201811335507.7

Wan Q.H., Huo Z.X, Chen L., A preparation method for monodispersed porous silica microspheres. 2020-3-31, Chinese, ZL 201810423795.5

Chen L., Jiang Y.T., Wan Q.H. Porous organic-inorganic hybridization silicon microsphere preparation method. 2017-5-10, Chinese, ZL 2015 1 0216610.X

Chen L., Jia G.Y., Wan Q.H. Method for preparing monodisperse hybrid silica gel microspheres through self-hydrolysis of methoxy-organosilane. 2017-7-28, Chinese, ZL 2015 1 0178500.9

Wan Q.H., Chen L., Zhang Z.C., Li W.B. A preparation method for ferromagnetic porous silica microspheres. 2003-7-21, Chinese, ZL 03 1 30422.2

Wan Q.H., Chen L., Li W.B., Zhang Z.C. A preparation method for ferromagnetic urea-formaldehyde resin. 2003-7-21, Chinese, ZL 03 1 30423.0

Highlighted Publications

H. Bai, Y. N. Zhao, L. Chen*. Single-column analysis strategy of star hydroxypropyl cyclodextrin polymer chiral stationary phase to the simultaneous separation of three-pair chiral alkaloid enantiomers. Talanta 2025. 295, 128369. https://doi.org/10.1016/j.talanta.2025.128369.

H. Bai, L. Chen*. Stereoisomeric separation and chiral recognition mechanism study of star cyclodextrin polymer as the chiral stationary phase. Analytica Chimica Acta 2024. 1329, 343249. https://doi.org/10.1016/j.aca.2024.343249.

C.Q. Chang, X.H. Jin, H. Bai, F. Zhang, L. Chen*. Molecular dynamics simulation for the acidic compounds retention mechanism study on octyl-quaternary ammonium mixed-mode stationary phase.Journal of Chromatographic Science 2024.62(10):962-971. https://doi.org/10.1093/chromsci/bmae036

C.D. Qi, L. Chen*. Progress of ligand‑modified agarose microspheres for protein isolation and purification. Microchimica Acta 2024, 191:149. https://doi.org/10.1007/s00604-024-06224-4.

X.D. Li, X.J. Deng, L. Chen*. Sunflower‑like missing‑linker covalent organic framework for efficient extraction of non‑steroidal anti‑inflammatory drugs. Environmental Science and Pollution Research 2024,31,16613-16628. https://doi.org/10.1007/s11356-024-32312-2.

X. Guo, H. Bai, L. Chen*, Imidazole-octyl mixed-mode stationary phase based on macroporous silica for purification of ovomucoid and ovotransferrin. Microchimica Acta 2023, 190, 404. https://doi.org/10.1007/s00604-023-05986-7.

L.X. Zhang , X.D. Li , L. Chen*, Fabrication of mixed-mode amphoteric β-cyclodextrin polymer for the simultaneous extraction of acidic and alkaline drugs. Journal of Chromatography B 2023, 1228,123833. https://doi.org/10.1016/j.jchromb.2023.123833.

Y. Jing, X. Guo, C.D. Qi, L. Chen*, Fabrication of silica microspheres for HPLC packing with narrow particle size distribution and different pore sizes by hard template method for protein separation. Chromatographia 2022, 85, 985-995. https://doi.org/10.1007/s10337-022-04200-9.

J.J. Shi, L.X. Zhang, Z.X. Huo, L. Chen*, High stability amino-derived reversed-phase/anion-exchange mixed-mode phase based on polysilsesquioxane microspheres for simultaneous separation of compound drugs. Journal of Pharmaceutical and Biomedical Analysis 2021, 203, 114187. https://doi.org/10.1016/j.jpba.2021.114187.

H. Bai, L. Chen*, Simultaneous separation of atenolol enantiomers and its acid/alkaline degradation impurities on mixed-mode chiral ligand exchange stationary phases. Chirality 2021,33, 710-721. https://doi. org/10.1002/chir.23353.

R.T. Bai, C.Q. Chang, L. Chen*, Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater. Journal of Separation Science 2020, 43, 3765-3774. https://doi.org/10.1002/jssc.202000589.

Z.X. Huo, Q.H. Wan, L. Chen*, Energy-efficient and environment-friendly method to prepare monodispersed silica stationary phases for simultaneous separation of compound drugs. Journal of Chromatography A 2020, 1618, 460866. https://doi.org/10.1016/j.chroma.2020.460866.

Z.X. Huo, L. Chen*, Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres. Journal of Separation Science 2020, 43, 389-397. https://doi.org/10.1002/jssc.201900634.

F. Zhang, L.Chen*, Synthesis of octyl-quaternary ammonium mixed-mode stationary phase by vapor deposition approach and its application in compound preparation separation. Chromatographia 2019, 82, 1437-1447. https ://doi.org/10.1007/s1033 7-019-03774 -1.

Y. Li, S-H Zhang, L. Chen*, An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations. Analytical Methods 2019, 11, 3898-3909.

Y. Li, L. Chen*, Separation and identification of oligomeric hindered amine light stabilizer uvasorb HA 88 by high-performance liquid chromatography (HPLC) coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Analytical Letters 2019, 52, 2546-2561. https://www.tandfonline.com/loi/lanl20.

M. Chen, L. Chen*, A novel high hydrothermal stability amino-functionalized stationary phase prepared by a vapour deposition method. Analytical Methods 2018,10,1538-1546.

Z. X. Huo, Q. H. Wan, L. Chen*, Synthesis and evaluation of porous polymethylsisesquioxane microspheres as low silano activity chromatographic stationary phase for basic compound separation. Journal of Chromatography A 2018, 1553, 90-100. https://doi.org/10.1016/j.chroma.2018.04.024.

L. Jun, L Chen*. Monitoring structural evolution of organosilicate species during sol–gel processes by electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry 2016, 30, 504-510.

X.H. Wang, Q.X. Fang, S.P. Liu, L. Chen*.The application of pseudo template molecularly imprinted polymer to the solid-phase extraction of cyromazine and its metabolic melamine from egg and milk. Journal of Separation Science 2012, 35, 1432-1438.

X.H. Wang, Q.X. Fang, S.P. Liu, L. Chen*. Preparation of magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples. Analytical and Bioanalytical Chemistry 2012, 404, 1555-1564.

Z.Q. Guo, D.Xu., Q.H. wan, L. Chen*. Separation of dihydroergotoxine on polar- embedded reversed-phase stationary phase. Chinese Journal of Analytical Chemistry 2009, 37(2), 232-236.

H.L. Wang, J.J. Cao, Y.P. Bi, L. Chen*, Q.H. Wan∗. Magnetically immobilized frits for the preparation of packed columns used in capillary electrochromatography. Journal of Chromatography A 2009, 1216 (31), 5882-5887.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2016	Monitoring structural evolution of organosilicate species during sol-gel processes by electrospray ionization mass spectrometry	Li, Jun; Chen, Lei	Rapid Communications in Mass Spectrometry	30
2012	Preparation of a magnetic molecularly imprinted polymer with pseudo template for rapid simultaneous determination of cyromazine and melamine in bio-matrix samples	Wang, Xianhua; Fang, Qiuxue; Liu, Shipeng; et al.	Analytical and Bioanalytical Chemistry	404
2012	Restricted access magnetic materials prepared by dual surface modification for selective extraction of therapeutic drugs from biological fluids	Wang, Yu; Wang, Yuxia; Chen, Lei; et al.	Journal of Magnetism and Magnetic Materials	324
2012	The application of pseudo template molecularly imprinted polymer to the solid-phase extraction of cyromazine and its metabolic melamine from egg and milk	Wang, Xianhua; Fang, Qiuxue; Liu, Shipeng; et al.	Journal of Separation Science	35
2011	Field-flow fractionation of magnetic particles in a cyclic magnetic field	Bi, Yanping; Pan, Xiaoxia; Chen, Lei; et al.	Journal of Chromatography a	1218
2010	Templated synthesis of monodisperse mesoporous maghemite/silica microspheres for magnetic separation of genomic DNA	Chen, Feng; Shi, Ruobing; Xue, Yun; et al.	Journal of Magnetism and Magnetic Materials	322
2009	Endcapping of Octadecyl Bonded Silica by Atomic Layer Deposition for Separation of Basic Compounds	Guo Zhi-Qiang; Chen Lei; Wan Qian-Hong	Chinese Journal of Analytical Chemistry	37
2009	Magnetically immobilized frits for the preparation of packed columns used in capillary electrochromatography	Wang, Hongling; Cao, Jingjing; Bi, Yanping; et al.	Journal of Chromatography a	1216
2009	Preparation of magnetite-loaded silica microspheres for solid-phase extraction of genomic DNA from soy-based foodstuffs	Shi, Ruobing; Wang, Yucong; Hu, Yunli; et al.	Journal of Chromatography a	1216
2009	Separation of Dihydroergotoxine on Polar Embedded Reversed-Phase Stationary Phase	Guo Zhi-Qiang; Xu Dan; Wan Qian-Hong; et al.	Chinese Journal of Analytical Chemistry	37
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Lei Chen——Associate Professor

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