TJU HEALTH SCIENCES PLATFORM

Introduction

Qingzhi Gao——Professor
Nationality:	CHINA
Phone:	022-27892050
Email:	qingzhi@tju.edu.cn
Office:	Room A609, Building 24, Tianjin University
School:	School of Pharmaceutical Science and Technology
ResearcherID:	K-1596-2015
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Education Experience

1994	Ph. D.	Nagoya University, JP
1994-1999	Postdoctoral	Stanford University, USA

Professional Experience

1994-2001	Research Scientist	Tokyo, JAPAN
1999-2000	Postdoctoral fellow	Stanford University, California, USA
2001-2009	Senior Research Scientist	XenoPort, Inc. California, USA
2009-2015	Professor	Tianjin University, Tianjin, CHINA
2010-2015	Director	Tianjin Key Laboratory

Research Area

The research of the Gao group covers medicinal chemistry and molecular targeting, synthetic chemistry and organo catalysis, and computer-aided drug design, aimed at the discovery of functional drug delivery carriers and understanding mechanisms of molecular targeting. Specific areas include a) strategies for development of small molecular anti-cancer drugs for targeted therapy, b) design and development of actively transportable small molecule drugs or protein-drug conjugates, c) discovery and development of novel drug-delivery carriers and pharmaceutics based on supramolecular chemistry, d) computer aided molecular design and modeling for innovative drug discovery and mechanistic study of drug transporters.

Honors and Awards

Patents

Highlighted Publications

Qian Mi, Yuru Ma, Ran Liu, Xiangqian Gao, Pengxing Liu, Yi Mi, Xuegang Fu, and QingzhiGao*, 2-Deoxyglucose Conjugated Platinum (II) Complexes for Targeted Therapy: Design, Synthesis, and Antitumor Activity. Journal of Biomolecular Structure & Dynamics, 2015, 30,1-12.

Hong Li, Xiangqian Gao, Ran Liu, Yu Wang, Menghua Zhang, Zheng Fu, Yi Mi, Yiqiang Wang, Zhi Yao, Qingzhi Gao*, Glucose conjugated platinum(II) complex: Antitumor superiority to oxaliplatin, combination effect and mechanism of action. European Journal of Medicinal Chemistry, 2015, 101, 400-408.

Liu, P.; Lu, Y.; Li, H.; Gao, X.; Liu, R.; Zhang-Negrerie, D.; Shi, Y.; Wang, Y.; Wang, S.; Gao, Q. Highly Water-soluble Platinum(II) Complex as GLUT Substrate for Targeted Therapy: Improved Anticancer Efficacy and Ttransporter-mediated Cytotoxic Properties. Chem. Commun. 2013, 49, 2421.

Lu, Y.; Gao, X.; Wu, M.; Zhang-Negrerie, D.; Gao, Q. Strategies on the Development of Small Molecule Anticancer Drugs for Targeted Therapy. Mini-Rev in Med. Chem. 2011, 11, 611.

Qingzhi Gao, Q.; Yang, L.; Zhu, Y. Pharmacophore Based Drug Design Approach as a Practical Process in Drug Discovery Current. Comput-Aided Drug Design 2010, 6, 37.

Ye, Y.; Wei, J.; Dai, X.; Gao, Q. Computational Studies of the Binding Modes of A2A Adenosine Receptor Antagonists. Amino Acids 2008, 35, 389.

Wei, J.; Wang, S.; Gao, S.; Dai X.; Qingzhi Gao, Q. 3D-Pharmacophore Models for Selective A2A and A2B Adenosine Receptor Antagonists. J. Chem. Inf. Model 2007, 47, 613.

ResearcherID Publications

Year	Title	Author(s)	Source	Volume
2007	3D-pharmacophore models for selective A(2A) and A(2B) adenosine receptor antagonists	Wei, Jing; Wang, Songqing; Gao, Shaofen; et al.	Journal of Chemical Information and Modeling	47
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Qingzhi Gao——Professor

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