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Kang Zhao——Professor
Nationality:
USA
Phone:
022-27404031
Email:
kangzhao@tju.edu.cn
Office:
Room 453, Building 11, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
K-3777-2015
Group weblink
Education Experience
1988 Ph. D. Columbia University, NY, USA
1988 Postdoctoral Columbia University, NY, USA
Professional Experience
2001-2015 Professor Tianjin University
2001-2003 Dean Tianjin University
2001-2003 Director TEDA, Tianjin
1995-1999 Professor W. M. Keck Foundation Early
1990-1992 Fellow Columbia Univ
Research Area

The research in the group of Zhao is encompassed in 4 main areas, including 1) Medicinal Chemistry:  Design and synthesis of drug molecules, and development of synthetic route to drug intermediates, 2) Biological Organic Chemistry:  Investigation of anti-cocaine, monoclonal antibodies, and anti-viruses, 3) Organic Synthetic Methodology: Hypervalent iodine chemistry and heterocyclic chemistry, and 4) Total Synthesis of Complex Molecules: design and synthesis of natural products.

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Honors and Awards
杜云飞，四乙酰核糖和二乙酰阿昔洛韦合成的新工艺，天津市人民政府，科技进步奖，二等奖，2010。（赵康、陈维瑜、魏静、杜云飞、王松青、苏艳芳、张秀东、陈炎泉）
Patents
杜云飞，马辉，赵康，异吲哚啉羧酸酯衍生物的制备方法及其应用，中国，201 010187238.1。
杜云飞，汤丽娜，庞永乐，阎俏，祁秀香，一种合成Coumestan类衍生物的新方 法，中国，201010171129.0。
祁秀香，杜云飞，闫俏，赵康，李慧，合成N-芳基吲哚-3-腈衍生物的方法，中 国，201010560853.2。
杜云飞，云希柳，毕文英，赵康，一种氮取代四氢咔唑酮衍生物的制备新方法 ，中国，201010252043.0。
杜云飞，赵康，赵菲菲，刘昕，齐蕊，2-三氟甲基噁唑类衍生物的合成方法， 中国，201110120698.7。
杜云飞，刘乐，贺巧巧，赵康，1,3-二腈基2-取代-1H-茚类衍生物及其制备方 法，中国，201210044059.1。
杜云飞，吕晶磊，尚巳耘，赵康，一种四氢-γ-咔啉类衍生物的合成方法，中 国，201310022038.4。
杜云飞，李旭明，张翔，赵康，一种二苯西平类衍生物的合成方法，中国，2013 10455049.1。
杜云飞，吕晶磊，赵康，一种2-吲哚酮-3-羧酸酯类衍生物的合成方法，中国，2 01310503250.2。
杜云飞，尚巳耘，赵康，一种合成二苯并二氢-1,3-二氮杂䓬类衍生物的方法， 中国，201310608894.8。
杜云飞，程然，赵康，一种通过环合消除一锅法合成4（3H）-喹唑啉酮衍生物的 方法，中国，201410113565.0。
杜云飞，程然，赵康，一种通过环合消除一锅法合成4（3H）-喹唑啉酮衍生物的 方法，中国，201410113565.0。
杜云飞，袁玉成，赵康，一种通过C–N氧化偶联合成取代二氨基烯烃衍生物的方 法，中国，2014104793464
Highlighted Publications
Shang, S.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. Intramolecular Metal-free Oxidative Aryl-aryl Coupling: An Unusual Hypervalent Iodine-mediated Rearrangement of 2-Substituted N-Phenylbenzamides. Angew. Chem., Int. Ed. 2014, 53, 6216 (Hot Paper).
Liu, L.; Lu, H.; Wang, H.; Yang, C.; Zhang, X.; Zhang-Negrerie, D.; Du, Y.; Zhao, K. PhI(OCOCF3)2-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones. Org. Lett. 2013, 15, 2906.
Du, Y.-F.; Liu, R.-H.; Linn, G.; Zhao, K. Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization. Org. Lett. 2006, 8, 5919.
Landry, D. W.; Zhao, K.; Yang, G. X. Q.; Glickman, M; Georgiadis, T. M. Antibody-Catalyzed Degradation of Cocaine. Science 1993, 259, 1899.
Stork, G.; Zhao, K. Total Synthesis of (-)-Histrionicotoxin and (-)-Histrionicotoxin 235A. J. Am. Chem. Soc. 1990, 112, 5875.
ResearcherID Publications
Year Title Author(s) Source Volume
2013 Synthesis of Diversely Substituted Indoloquinolinones via Pd(II)/Cu(II)-Mediated Oxidative C-C Bond Formation and I(III)-Mediated C-N Bond Formation Zhang, Xiang; Zhang-Negrerie, Daisy; Deng, Jun; et al. Journal of Organic Chemistry 78
2013 Synthesis of coumarins via PIDA/I-2-mediated oxidative cyclization of substituted phenylacrylic acids Li, Jinming; Chen, Huiyu; Zhang-Negrerie, Daisy; et al. Rsc Advances 3
2013 Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction Zhang, Nana; Yu, Qingzhen; Chen, Ruixue; et al. Chemical Communications 49
2013 Phl(OCOCF3)(2)-Mediated C-C Bond Formation Concomitant with a 1,2-Aryl Shift in a Metal-Free Synthesis of 3-Arylquinolin-2-ones Liu, Le; Lu, Hang; Wang, Hong; et al. Organic Letters 15
2013 One-Pot Synthesis of Quinazolinones from Anthranilamides and Aldehydes via p-Toluenesulfonic Acid Catalyzed Cyclocondensation and Phenyliodine Diacetate Mediated Oxidative Dehydrogenation Cheng, Ran; Guo, Tianjian; Zhang-Negrerie, Daisy; et al. Synthesis-Stuttgart 45
2013 Pd-catalysed direct dehydrogenative carboxylation of alkenes: facile synthesis of vinyl esters Yang, Dan; Ding, Shixuan; Huang, Jianhui; et al. Chemical Communications 49
2013 One-pot synthesis of isoxazoles from enaminones: an application of Fe(II) as the catalyst for ring expansion of 2H-azirine intermediates Zheng, Yunhui; Yang, Chao; Zhang-Negrerie, Daisy; et al. Tetrahedron Letters 54
2013 One-Pot Synthesis of 3-Hydroxyquinolin-2(1H)-ones from N-Phenylacetoacetamide via PhI(OCOCF3)(2)-Mediated alpha-Hydroxylation and H2SO4-Promoted Intramolecular Cyclization Yuan, Yucheng; Yang, Rui; Zhang-Negrerie, Daisy; et al. Journal of Organic Chemistry 78
2013 Formation of Functionalized 2H-Azirines through PhIO-Mediated Trifluoroethoxylation and Azirination of Enamines Sun, Xiaoqian; Lyu, Youran; Zhang-Negrerie, Daisy; et al. Organic Letters 15
2013 Efficient Synthesis of Hydroxyl Isoindolones by a Pd-Mediated C-H Activation/Annulation Reaction Yu, Qingzhen; Zhang, Nana; Huang, Jianhui; et al. Chemistry-a European Journal 19

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