Zhiyuan Shi——Yingcai Associate Professor
Nationality:
Phone:
Email:
zhiyuan_shi2023@tju.edu.cn
Office:
Room 310-5, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
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Education Experience
2017-2020 Doctor of Science Chemistry RWTH Aachen University, Germany
2014-2017 Master of Science Biomedical Engineering RWTH Aachen University, Germany
2011-2014 Bachelor of Science Biology University of Göttingen, Germany
Professional Experience
2020-2022 Research Scientist / Project Leader Department I for Internal Medicine, University of Cologne, Germany
2017-2020 Research Assistant / PostDoc researcher RWTH Aachen University & DWI-Leibniz institute for Interactive Materials e.V., Aachen, Germany
Research Area

1. 声药理学：用高分子机械力化学的方法控释药物（Sonopharmacology: using the principle of polymer mechanochemistry for the activation of drugs）
2. 癌症免疫疗法：双克隆抗体研发用于癌症免疫疗法(Cancer immunotherapy: bispecific antibody engineering for cancer immunotherapy)
Honors and Awards
Borchers-Plakette from RWTH Aachen university 2021 (Borchers-Plakette 奖章）
Chinese government award for outstanding self-financed students abroad 2020（国家优秀自费留学生奖学金）
Lower Saxony Scholarship 2012 （德国下萨克森州奖学金）
Lower Saxony Scholarship 2011 （德国下萨克森州奖学金）
Patents
Highlighted Publications
Zhiyuan Shi*, Yong Hu*, Xin Li*. Polymer mechanochemistry in drug delivery: From controlled release to precise activation. J. Control. Release 365, 259–273 (2024).
Zhiyuan Shi*, Helin Li, Xin Li*. Sonopharmacology: Polymer mechanochemistry for drug activation. Mater. Today 64, 10–12 (2023).
Zhiyuan Shi, Jingnan Wu, Qingchuan Song, Robert Göstl*, and Andreas Herrmann*. Toward drug release using polymer mechanochemical disulfide scission. J Am Chem Soc 142, 14725–14732 (2020).
Shuaidong Huo†, Pengkun Zhao†, Zhiyuan Shi†, Miancheng Zou, Xintong Yang, Eliza Warszawik, Mark Loznik, Robert Göstl*, and Andreas Herrmann*. Mechanochemical bond scission for the activation of drugs. Co-first author. Nat. Chem. 13, 131–139 (2021).
Zhiyuan Shi, Qingchuan Song, Robert Göstl*, and Andreas Herrmann*. Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release. Chem. Sci. 12, 1668-1674 (2021).
Zhiyuan Shi, Qingchuan Song, Robert Göstl*, and Andreas Herrmann*. The mechanochemical release of naphthalimide fluorophores from β-carbonate and β-carbamate disulfide-centered polymers. CCS Chem. 3, 2333–2344 (2021).