Shishir Sharma—— |
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Nationality:
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NEPAL
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Phone:
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13207506322
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Email:
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shistc412@hotmail.com
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Office:
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24-C403
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School:
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School of Pharmaceutical Science and Technology
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ResearcherID:
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Group weblink
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Education Experience
| 2015-2022 | Ph. D. Applied Chemistry | Tianjin University |
| 2002-2004 | Master of Science Microbiology | Tribhuvan University |
| 1999-2002 | Bachelor of Science Microbiology | Tribhuvan University |
Professional Experience
| 2015-2015 | Deputy Head | Department of Biotechnology, AITM |
| 2009-2015 | Visiting Faculty for Graduate Program | Tribhuvan University, Central Department of Biotechnology |
| 2007-2015 | Visiting Faculty for Undergraduate Program | Tribhuvan University, Amrit Science College |
| 2010-2015 | Full time faculty | Biotechnology Department, AITM, Affiliated to Pokhara University |
Research Area
Honors and Awards
| University Grants Commission Nepal funded Faculty Research Grant, 2013 |
| Ministry of Science, Technology and Environment, MoST Nepal funded grant, 2011 and 2012 |
Patents
Highlighted Publications
| Sharma, S.; Sijie, L.; Durairaj, P.; Machalz, D.; Wolber, G.; Bureik, M. A convenient test system for the identification of CYP4V2 inhibitors. Mol. Vis. 2021, 27: 601-607. PMID: 34880593 |
| Sharma, S.; Sharma, S. S.; Zhang, X.; Bureik, J.-P.; Sorensen, E. J.; Bureik, M., Conversion of five proluciferin esters by human cytochrome P450 enzymes. Biotechnology Journal 2021, 16(7):e2100007. doi: 10.1002/biot.202100007. |
| Machalz, D.; Li, H.; Du, W.; Sharma, S.; Liu, S.; Bureik, M.; Wolber, G., Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor. Eur J Med Chem 2021, 215, 113255. doi: 10.1016/j.ejmech.2021.113255. |
| Sharma, S.; Liu, J.; Zhang, X.; Sharma, S. S.; Sorensen, E. J.; Bureik, M., New luciferin-based probe substrates for human CYP26A1. Biochem Biophys Rep 2020, 24, 100861. doi: 10.1016/j.bbrep.2020.100861. |
| Sharma, S.; Durairaj, P.; Bureik, M., Rapid and convenient biotransformation procedure for human drug metabolizing enzymes using permeabilized fission yeast cells. Analytical biochemistry 2020, 607, 113704. doi: 10.1016/j.ab.2020.113704. |
| Sharma, S. S.; Sharma, S.; Bureik, M., Screening of the whole human cytochrome P450 complement (CYPome) with enzyme bag cocktails. Journal of pharmaceutical analysis 2020, 10 (3), 271-276. doi:10.1016/j.jpha.2020.05.003. |
| Durairaj, P.; Fan, L.; Du, W.; Ahmad, S.; Mebrahtu, D.; Sharma, S.; Ashraf, R. A.; Liu, J.; Liu, Q.; Bureik, M., Functional expression and activity screening of all human cytochrome P450 enzymes in fission yeast. FEBS letters 2019, 593 (12), 1372-1380. doi: 10.1002/1873-3468.13441. |
| Anurag Adhikari, Birendra Prasad Gupta, Krishna Das Manandhar, Shravan Kumar Mishra, Hari Krishna Saiju, Rajendra Maan Shrestha, Nawneet Mishra and Shishir Sharma. Negative feedback circuit for toll like receptor-8 activation in human embryonic Kidney 293 using outer membrane vesicle delivered bi-specific siRNA. BMC Immunology (2015) 16:4. doi: 10.1186/s12865-015-0109-9 |
| Baplu Rai, Ashish Shrestha , Shishir Sharma, Jarina Joshi. Screening, optimization and process scale up for pilot scale production of lipase by Aspergillus niger. Biomedicine and Biotechnology 2, no 3 (2014):54-59. doi: 10.12691/bb-2-3-3 |