Xin Mu——Associate Professor
Nationality:
Chinese
Phone:
Email:
xin_mu@tju.edu.cn
Office:
Building 24, Room 310-4
School:
School of Pharmaceutical Science and Technology
ResearcherID:
Group weblink
Education Experience
2001-2005 Bachelor of Science Pharmaceutical Tianjin University
2005-2013 Ph. D. Biochemistry and Molecular Biology Institute of Biophysics, CAS
Professional Experience
2013-2014 Research Assistant Institute of Biophysics, CAS
2014-2015 Post-doc Institute of Microbiology, CAS
2015-2019 Post-doc Boston Children's Hospital / Harvard Medical School
Research Area

Our laboratory is interested in the cellular innate immune events that sense viral infection and inhibit viral replication. 

We are particularly focusing on the following two aspects: (1) endogenous suppressors that modulate innate immune signaling, and (2) molecular mechanism of autoimmune disorders caused by aberrant immune responses.
Honors and Awards
Patents
Highlighted Publications
Mu X, Hur S. Immunogenicity of In Vitro-Transcribed RNA. Acc Chem Res. 2021 Nov 2;54(21):4012-4023.
Mu X, Greenwald E, Ahmad S, Hur S. An origin of the immunogenicity of in vitro transcribed RNA. Nucleic Acids Res 2018, 46(10):5239-5249.
Ahmad S*, Mu X*, Yang F*, Greenwald E, Park J W, Jacob E, Zhang C, Hur S. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell 2018, 172(4):797-810 e13. (*: co-first author)
Mu X, Ahmad S, Hur S. Endogenous Retroelements and the Host Innate Immune Sensors. Adv Immunol 2016, 132, 47-69
Mu X, Fu Y, Zhu Y, Wang X, Xuan Y, Shang H, Goff SP, Gao G: HIV-1 Exploits the Host Factor RuvB-like 2 to Balance Viral Protein Expression. Cell Host Microbe 2015, 18(2):233-242.
Mu X*, Li W*, Wang X, Gao G: YB-1 stabilizes HIV-1 genomic RNA and enhances viral production. Protein Cell 2013, 4(8):591-597. (*: co-first author)