Lei Chen——Associate Professor
Nationality:
CHINA
Phone:
Email:
chenlei@tju.edu.cn
Office:
Room 412-2, Building 24, Tianjin University
School:
School of Pharmaceutical Science and Technology
ResearcherID:
K-2114-2015
Group weblink
Education Experience
2003-2006 Ph. D. Applied Chemistry Tianjin University, CN
Professional Experience
2006- Associate Professor SPST,Tianjin Univ.
2013-2014 Visiting Scholar UCSB,USA
Research Area

The research of the Chen group is focused on synthesis of biomaterials and development of modern separation and analysis technology.  In particular, efforts include a) development of different methods to control the morphology and pore structure of the HPLC stationary phase,  b) design  mixed-mode chromatography (MMC) according to the structure of analytes and investigation into their mechanism,  and c) exploitation of magnetic separation technology in the purification of biological samples. Additionally, efforts are extended towards chiral analysis of pharmacological compounds, including synthesis of chiral stationary phase of HPLC, and optimization of separation and identification methods in HPLC and LC-MS.


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Honors and Awards
Patents
Chen L.,Huo Z.X., Wan Q.H, Micron-scale monodispersed porous silica microsphere and its preparation method. 2022-1-11, Chinese, ZL 201811335507.7
Wan Q.H., Huo Z.X, Chen L., A preparation method for monodispersed porous silica microspheres. 2020-3-31, Chinese, ZL 201810423795.5
Chen L., Jiang Y.T., Wan Q.H. Porous organic-inorganic hybridization silicon microsphere preparation method. 2017-5-10, Chinese, ZL 2015 1 0216610.X
Chen L., Jia G.Y., Wan Q.H. Method for preparing monodisperse hybrid silica gel microspheres through self-hydrolysis of methoxy-organosilane. 2017-7-28, Chinese, ZL 2015 1 0178500.9
Wan Q.H., Chen L., Zhang Z.C., Li W.B. A preparation method for ferromagnetic porous silica microspheres. 2003-7-21, Chinese, ZL 03 1 30422.2
Wan Q.H., Chen L., Li W.B., Zhang Z.C. A preparation method for ferromagnetic urea-formaldehyde resin. 2003-7-21, Chinese, ZL 03 1 30423.0
Highlighted Publications
H. Bai, L. Chen*. Stereoisomeric separation and chiral recognition mechanism study of star cyclodextrin polymer as the chiral stationary phase. Analytica Chimica Acta 2024. 1329, 343249.
C.Q. Chang, X.H. Jin, H. Bai, F. Zhang, L. Chen*. Molecular dynamics simulation for the acidic compounds retention mechanism study on octyl-quaternary ammonium mixed-mode stationary phase.Journal of Chromatographic Science 2024. DOI: 10.1093/chromsci/bmae036
C.D. Qi, L. Chen*. Progress of ligand‑modified agarose microspheres for protein isolation and purification. Microchimica Acta 2024, 191:149.
X.D. Li, X.J. Deng, L. Chen*. Sunflower‑like missing‑linker covalent organic framework for efficient extraction of non‑steroidal anti‑inflammatory drugs. Environmental Science and Pollution Research 2024,31,16613-16628.
X. Guo, H. Bai, L. Chen*, Imidazole-octyl mixed-mode stationary phase based on macroporous silica for purification of ovomucoid and ovotransferrin. Microchim. Acta 2023, 190, 404.
L.X. Zhang , X.D. Li , L. Chen*, Fabrication of mixed-mode amphoteric β-cyclodextrin polymer for the simultaneous extraction of acidic and alkaline drugs. J. Chromatogr. B 2023, 1228,123833.
Y. Jing, X. Guo, C.D. Qi, L. Chen*, Fabrication of silica microspheres for HPLC packing with narrow particle size distribution and different pore sizes by hard template method for protein separation. Chromatographia 2022, 85, 985-995.
J.J. Shi, L.X. Zhang, Z.X. Huo, L. Chen*, High stability amino-derived reversed-phase/anion-exchange mixed-mode phase based on polysilsesquioxane microspheres for simultaneous separation of compound drugs. J. Pharmaceut. Biomed.2021, 203, 114187.
H. Bai, L. Chen*, Simultaneous separation of atenolol enantiomers and its acid/alkaline degradation impurities on mixed-mode chiral ligand exchange stationary phases. Chirality 2021,33, 710-721.
R.T. Bai, C.Q. Chang, L. Chen*, Preparation of highly responsive monodisperse magnetic porous silica microspheres for the enrichment of cephalosporins in wastewater. J. Sep. Sci. 2020, 43, 3765-3774.
Z.X. Huo, Q.H. Wan, L. Chen*, Energy-efficient and environment-friendly method to prepare monodispersed silica stationary phases for simultaneous separation of compound drugs. J. Chromatogr. A 2020, 1618, 460866.
Z.X. Huo, L. Chen*, Base-deactivated and alkaline-resistant chromatographic stationary phase based on functionalized polymethylsilsesquioxane microspheres. J. Sep. Sci. 2020, 43, 389-397.
F. Zhang, L.Chen*, Synthesis of octyl-quaternary ammonium mixed-mode stationary phase by vapor deposition approach and its application in compound preparation separation. Chromatographia 2019, 82, 1437-1447.
Y. Li, S-H Zhang, L. Chen*, An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations. Anal. Methods 2019, 11, 3898-3909.
Y. Li, L. Chen*, Separation and identification of oligomeric hindered amine light stabilizer uvasorb HA 88 by high-performance liquid chromatography (HPLC) coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Letters 2019, 52, 2546-2561.
M. Chen, L. Chen*, A novel high hydrothermal stability amino-functionalized stationary phase prepared by a vapour deposition method. Anal. Methods 2018,10,1538-1546.
Z. X. Huo, Q. H. Wan, L. Chen*, Synthesis and evaluation of porous polymethylsisesquioxane microspheres as low silano activity chromatographic stationary phase for basic compound separation. J. Chromatogr. A 2018, 1553, 90-100.